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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neuropathol+Exp+Neurol
2016 ; 75
(7
): 628-35
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gab.com Text
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Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological
Features From a Large Autopsy Study
#MMPMID27283329
Rodriguez RD
; Suemoto CK
; Molina M
; Nascimento CF
; Leite RE
; de Lucena Ferretti-Rebustini RE
; Farfel JM
; Heinsen H
; Nitrini R
; Ueda K
; Pasqualucci CA
; Jacob-Filho W
; Yaffe K
; Grinberg LT
J Neuropathol Exp Neurol
2016[Jul]; 75
(7
): 628-35
PMID27283329
show ga
Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy
reported in Caucasians with high educational attainment. Little is known about
AGD in non-Caucasians or in those with low educational attainment. We describe
AGD demographics, clinical, and neuropathological features in a multiethnic
cohort of 983 subjects ?50 years of age from São Paulo, Brazil. Clinical data
were collected through semistructured interviews with an informant and included
in the Informant Questionnaire on Cognitive Decline in the Elderly, the Clinical
Dementia Rating, and the Neuropsychiatric Inventory. Neuropathologic assessment
relied on internationally accepted criteria. AGD was frequent (15.2%) and was the
only neuropathological diagnosis in 8.9% of all cases (mean, 78.9 ± 9.4 years);
it rarely occurred as an isolated neuropathological finding. AGD was associated
with older age, lower socioeconomic status (SES), and appetite disorders. This is
the first study of demographic, clinical, and neuropathological aspects of AGD in
different ethnicities and subjects from all socioeconomic strata. The results
suggest that prospective studies of AGD patients include levels of hormones
related to appetite control as possible antemortem markers. Moreover,
understanding the mechanisms behind higher susceptibility to AGD of low SES
subjects may disclose novel environmental risk factors for AGD and other
neurodegenerative diseases.