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10.1111/imm.12598 http://scihub22266oqcxt.onion/10.1111/imm.12598 C4913288!4913288 !26878424     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26878424 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2016 ; 148 (3 ): 253-65 Nephropedia Template TP {{tp|p=26878424 |t=2016. Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1 |pdf=|usr=}}{{26878424 }} gab.com Text Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1 JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26878424 #FOAvip Sertoli cells (SCs) possess inherent immunosuppressive properties and are major contributors to the immunoprivileged status of mammalian testis. SCs have been reported to inhibit the activation of B cells, T cells and natural killer cells but not dendritic cells (DCs). Herein, we present evidence that co-culture with SCs results in a persistent state of DC immaturity characterized by down-regulation of the surface molecules I-A/E, CD80, CD83, CD86, CCR7 and CD11c, as well as reduced production of pro-inflammatory cytokines. SC-conditioned DCs (SC-DCs) displayed low immunogenicity and enhanced immunoregulatory functions, including the inhibition of T-cell proliferation and the promotion of Foxp3(+) regulatory T-cell development. Mechanistically, the activation of p38, extracellular signal-regulated kinase 1/2, and signal transducer and activator of transcription 3 was suppressed in SC-DCs. More importantly, we demonstrate that galectin-1 secreted by SCs plays a pivotal role in the differentiation of functionally tolerogenic SC-DCs. These findings further support the role of SCs in maintaining the immunoprivileged environment of the testis and provide a novel approach to derive tolerogenic DCs, which may lead to alternative therapeutic strategies for the treatment of immunopathogenic diseases. Twit Text FOAVip Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1 ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26878424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26878424 #FOAvip English Wikipedia <ref>{{Cite pmid|26878424 }}</ref> Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1 #MMPMID26878424 Gao J ; Wang X ; Wang Y ; Han F ; Cai W ; Zhao B ; Li Y ; Han S ; Wu X ; Hu D Immunology 2016[Jul]; 148 (3 ): 253-65 PMID26878424 show ga Sertoli cells (SCs) possess inherent immunosuppressive properties and are major contributors to the immunoprivileged status of mammalian testis. SCs have been reported to inhibit the activation of B cells, T cells and natural killer cells but not dendritic cells (DCs). Herein, we present evidence that co-culture with SCs results in a persistent state of DC immaturity characterized by down-regulation of the surface molecules I-A/E, CD80, CD83, CD86, CCR7 and CD11c, as well as reduced production of pro-inflammatory cytokines. SC-conditioned DCs (SC-DCs) displayed low immunogenicity and enhanced immunoregulatory functions, including the inhibition of T-cell proliferation and the promotion of Foxp3(+) regulatory T-cell development. Mechanistically, the activation of p38, extracellular signal-regulated kinase 1/2, and signal transducer and activator of transcription 3 was suppressed in SC-DCs. More importantly, we demonstrate that galectin-1 secreted by SCs plays a pivotal role in the differentiation of functionally tolerogenic SC-DCs. These findings further support the role of SCs in maintaining the immunoprivileged environment of the testis and provide a novel approach to derive tolerogenic DCs, which may lead to alternative therapeutic strategies for the treatment of immunopathogenic diseases. |*Immune Tolerance [MESH] |Animals [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Cytokines/metabolism [MESH] |Dendritic Cells/*immunology [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Galectin 1/immunology/*metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Sertoli Cells/*immunology [MESH] |Signal Transduction [MESH] |T-Lymphocytes, Regulatory/*immunology [MESH]Murine Sertoli cells promote the development of tolerogenic dendritic (epmc).pdf DeepDyve Pubget Overpricing