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10.1038/srep28370 http://scihub22266oqcxt.onion/10.1038/srep28370 C4913257!4913257 !27321991     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27321991 &cmd=llinks): Failed to open stream: HTTP request failed! 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Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis |pdf=|usr=}}{{27321991 }} gab.com Text Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27321991 #FOAvip Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. However, the effect of alpinetin on inflammatory bowel disease (IBD) has not yet been reported. The purpose of this study was to investigate the anti-inflammatory effect and mechanism of alpinetin on dextran sulfate sodium (DSS)-induced colitis in mice. In vivo, DSS-induced mice colitis model was established by giving mice drinking water containing 5% (w/v) DSS for 7 days. Alpinetin (25, 50 and 100 mg/kg) were administered once a day by intraperitoneal injection 3 days before DSS treatment. In vitro, phorbol myristate acetate (PMA)-differentiated monocytic THP-1 macrophages were treated with alpinetin and stimulated by lipopolysaccharide (LPS). The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-?) and interleukin (IL-1?) production in mice. In vitro, alpinetin markedly inhibited LPS-induced TNF-? and IL-1? production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-?B) and NOD-like receptor protein 3 (NLRP3) inflammasome activation. In conclusion, this study demonstrated that alpinetin had protective effects on DSS-induced colitis and may be a promising therapeutic reagent for colitis treatment. Twit Text FOAVip Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27321991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27321991 #FOAvip English Wikipedia <ref>{{Cite pmid|27321991 }}</ref> Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis #MMPMID27321991 He X ; Wei Z ; Wang J ; Kou J ; Liu W ; Fu Y ; Yang Z Sci Rep 2016[Jun]; 6 (ä): 28370 PMID27321991 show ga Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. However, the effect of alpinetin on inflammatory bowel disease (IBD) has not yet been reported. The purpose of this study was to investigate the anti-inflammatory effect and mechanism of alpinetin on dextran sulfate sodium (DSS)-induced colitis in mice. In vivo, DSS-induced mice colitis model was established by giving mice drinking water containing 5% (w/v) DSS for 7 days. Alpinetin (25, 50 and 100 mg/kg) were administered once a day by intraperitoneal injection 3 days before DSS treatment. In vitro, phorbol myristate acetate (PMA)-differentiated monocytic THP-1 macrophages were treated with alpinetin and stimulated by lipopolysaccharide (LPS). The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-?) and interleukin (IL-1?) production in mice. In vitro, alpinetin markedly inhibited LPS-induced TNF-? and IL-1? production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-?B) and NOD-like receptor protein 3 (NLRP3) inflammasome activation. In conclusion, this study demonstrated that alpinetin had protective effects on DSS-induced colitis and may be a promising therapeutic reagent for colitis treatment. |*Signal Transduction [MESH] |Animals [MESH] |Cell Survival [MESH] |Colitis/chemically induced/*immunology [MESH] |Dextran Sulfate [MESH] |Female [MESH] |Flavanones/*pharmacology [MESH] |Humans [MESH] |Inflammasomes/metabolism [MESH] |Inflammation/*drug therapy [MESH] |Injections, Intraperitoneal [MESH] |Interleukin-1beta/metabolism [MESH] |Lipopolysaccharides [MESH] |Macrophages/metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |NF-kappa B/metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism [MESH] |Peroxidase/metabolism [MESH] |THP-1 Cells/cytology [MESH] |Tetradecanoylphorbol Acetate [MESH] |Toll-Like Receptor 4/*metabolism [MESH]Alpinetin attenuates inflammatory responses by suppressing TLR4 and NL(epmc).pdf DeepDyve Pubget Overpricing