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10.1038/srep27445 http://scihub22266oqcxt.onion/10.1038/srep27445 C4913243!4913243 !27321376     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27321376 &cmd=llinks): Failed to open stream: HTTP request failed! 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CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia |pdf=|usr=}}{{27321376 }} gab.com Text CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27321376 #FOAvip In addition to antiplatelet autoantibodies, CD8(+) cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction in immune thrombocytopenia (ITP). Recent studies have highlighted that platelet desialylation leads to platelet clearance via hepatocyte asialoglycoprotein receptors (ASGPRs). Whether CD8(+) T cells induce platelet desialylation in ITP remains unclear. Here, we investigated the cytotoxicity of CD8(+) T cells towards platelets and platelet desialylation in ITP. We found that the desialylation of fresh platelets was significantly higher in ITP patients with positive cytotoxicity of CD8(+) T cells than those without cytotoxicity and controls. In vitro, CD8(+) T cells from ITP patients with positive cytotoxicity induced significant platelet desialylation, neuraminidase-1 expression on the platelet surface, and platelet phagocytosis by hepatocytes. To study platelet survival and clearance in vivo, CD61 knockout mice were immunized and their CD8(+) splenocytes were used. Platelets co-cultured with these CD8(+) splenocytes demonstrated decreased survival in the circulation and increased phagocytosis in the liver. Both neuraminidase inhibitor and ASGPRs competitor significantly improved platelet survival and abrogated platelet clearance caused by CD8(+) splenocytes. These findings suggest that CD8(+) T cells induce platelet desialylation and platelet clearance in the liver in ITP, which may be a novel mechanism of ITP. Twit Text FOAVip CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27321376 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27321376 #FOAvip English Wikipedia <ref>{{Cite pmid|27321376 }}</ref> CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia #MMPMID27321376 Qiu J ; Liu X ; Li X ; Zhang X ; Han P ; Zhou H ; Shao L ; Hou Y ; Min Y ; Kong Z ; Wang Y ; Wei Y ; Liu X ; Ni H ; Peng J ; Hou M Sci Rep 2016[Jun]; 6 (ä): 27445 PMID27321376 show ga In addition to antiplatelet autoantibodies, CD8(+) cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction in immune thrombocytopenia (ITP). Recent studies have highlighted that platelet desialylation leads to platelet clearance via hepatocyte asialoglycoprotein receptors (ASGPRs). Whether CD8(+) T cells induce platelet desialylation in ITP remains unclear. Here, we investigated the cytotoxicity of CD8(+) T cells towards platelets and platelet desialylation in ITP. We found that the desialylation of fresh platelets was significantly higher in ITP patients with positive cytotoxicity of CD8(+) T cells than those without cytotoxicity and controls. In vitro, CD8(+) T cells from ITP patients with positive cytotoxicity induced significant platelet desialylation, neuraminidase-1 expression on the platelet surface, and platelet phagocytosis by hepatocytes. To study platelet survival and clearance in vivo, CD61 knockout mice were immunized and their CD8(+) splenocytes were used. Platelets co-cultured with these CD8(+) splenocytes demonstrated decreased survival in the circulation and increased phagocytosis in the liver. Both neuraminidase inhibitor and ASGPRs competitor significantly improved platelet survival and abrogated platelet clearance caused by CD8(+) splenocytes. These findings suggest that CD8(+) T cells induce platelet desialylation and platelet clearance in the liver in ITP, which may be a novel mechanism of ITP. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Asialoglycoprotein Receptor/immunology [MESH] |Blood Platelets/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Hep G2 Cells [MESH] |Hepatocytes/immunology [MESH] |Humans [MESH] |Liver/*immunology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Middle Aged [MESH] |Neuraminidase/immunology [MESH] |Phagocytosis/immunology [MESH] |Purpura, Thrombocytopenic, Idiopathic/*immunology [MESH]CD8(+) T cells induce platelet clearance in the liver via platelet des(epmc).pdf DeepDyve Pubget Overpricing