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10.4049/jimmunol.1502698 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502698 C4912958!4912958!27233961     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 197 (1): 141-50 Nephropedia Template TP {{tp|p=27233961|t=2016. mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development |pdf=|usr=}}{{27233961}} gab.com Text mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27233961 #FOAvip Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex 2 (mTORC2) signals to regulate cell survival, nutrient uptake, and metabolism. We report here that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which accompanies decreased TEC numbers in the medulla. Moreover, generation of multiple T cell lineages, including conventional TCR?? T cells, regulatory T cells, iNKT cells, and TCR?? T cells, was reduced in TEC-specific Rictor-deficient mice. Our data demonstrate that mTORC2 in TECs is important for normal thymopoiesis and efficient T cell generation. Twit Text FOAVip mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27233961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27233961 #FOAvip English Wikipedia <ref>{{Cite pmid|27233961}}</ref> mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development #MMPMID27233961 Wang HX; Cheng JS; Chu S; Qiu YR; Zhong XP J Immunol 2016[Jul]; 197 (1): 141-50 PMID27233961show ga Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex 2 (mTORC2) signals to regulate cell survival, nutrient uptake, and metabolism. We report here that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which accompanies decreased TEC numbers in the medulla. Moreover, generation of multiple T cell lineages, including conventional TCR?? T cells, regulatory T cells, iNKT cells, and TCR?? T cells, was reduced in TEC-specific Rictor-deficient mice. Our data demonstrate that mTORC2 in TECs is important for normal thymopoiesis and efficient T cell generation. ämTORC2 in thymic epithelial cells controls thymopoiesis and T cell dev(epmc).pdf DeepDyve Pubget Overpricing