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10.1016/j.cgh.2016.02.017 http://scihub22266oqcxt.onion/10.1016/j.cgh.2016.02.017 C4912917!4912917!26905907     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Gastroenterol+Hepatol 2016 ; 14 (7): 973-9 Nephropedia Template TP {{tp|p=26905907|t=2016. Statin use is Associated With Reduced Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases |pdf=|usr=}}{{26905907}} gab.com Text Statin use is Associated With Reduced Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases JO: Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26905907 #FOAvip Background & Aims: Inflammatory bowel diseases (IBDs) such as Crohn?s disease and ulcerative colitis are associated with an increased risk of colorectal cancer (CRC). Chemopreventive strategies have produced weak or inconsistent results. Statins have been inversely associated with sporadic CRC. We examined their role as chemopreventive agents in patients with IBD. Methods: We collected data from 11,001 patients with IBD receiving care at hospitals in the Greater Boston metropolitan area from 1998 through 2010. Diagnoses of CRC were determined using validated ICD-9-CM codes. Statin use prior to diagnosis was assessed through analysis of electronic prescriptions. We performed multivariate logistic regression analyses, adjusting for potential confounders including primary sclerosing cholangitis, smoking, increased levels of inflammation markers, and CRC screening practices to identify independent association between statin use and CRC. We performed sensitivity analyses using propensity score adjustment and variation in definition of statin use. Results: In our cohort 1376 of the patients (12.5%) received 1 or more prescriptions for a statin. Patients using statins were more likely to be older, male, white, smokers, and have greater comorbidity than non-users. Over a follow-up period of 9 years, 2% of statin users developed CRC compared to 3% of non-users (age-adjusted odds ratio, 0.35; 95% confidence interval, 0.24?0.53). On multivariate analysis, statin use remained independently and inversely associated with CRC (odds ratio, 0.42; 95% confidence interval, 0.28?0.62). Our findings were robust on a variety of sensitivity and subgroup analyses. Conclusions: Statin use is inversely associated with risk of CRC in a large IBD cohort. Prospective studies on the role of statins as chemopreventive agents are warranted. Twit Text FOAVip Statin use is Associated With Reduced Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases ????Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26905907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26905907 #FOAvip English Wikipedia <ref>{{Cite pmid|26905907}}</ref> Statin use is Associated With Reduced Risk of Colorectal Cancer in Patients with Inflammatory Bowel Diseases #MMPMID26905907 Ananthakrishnan AN; Cagan A; Cai T; Gainer VS; Shaw SY; Churchill S; Karlson EW; Murphy SN; Liao KP; Kohane I Clin Gastroenterol Hepatol 2016[Jul]; 14 (7): 973-9 PMID26905907show ga Background & Aims: Inflammatory bowel diseases (IBDs) such as Crohn?s disease and ulcerative colitis are associated with an increased risk of colorectal cancer (CRC). Chemopreventive strategies have produced weak or inconsistent results. Statins have been inversely associated with sporadic CRC. We examined their role as chemopreventive agents in patients with IBD. Methods: We collected data from 11,001 patients with IBD receiving care at hospitals in the Greater Boston metropolitan area from 1998 through 2010. Diagnoses of CRC were determined using validated ICD-9-CM codes. Statin use prior to diagnosis was assessed through analysis of electronic prescriptions. We performed multivariate logistic regression analyses, adjusting for potential confounders including primary sclerosing cholangitis, smoking, increased levels of inflammation markers, and CRC screening practices to identify independent association between statin use and CRC. We performed sensitivity analyses using propensity score adjustment and variation in definition of statin use. Results: In our cohort 1376 of the patients (12.5%) received 1 or more prescriptions for a statin. Patients using statins were more likely to be older, male, white, smokers, and have greater comorbidity than non-users. Over a follow-up period of 9 years, 2% of statin users developed CRC compared to 3% of non-users (age-adjusted odds ratio, 0.35; 95% confidence interval, 0.24?0.53). On multivariate analysis, statin use remained independently and inversely associated with CRC (odds ratio, 0.42; 95% confidence interval, 0.28?0.62). Our findings were robust on a variety of sensitivity and subgroup analyses. Conclusions: Statin use is inversely associated with risk of CRC in a large IBD cohort. Prospective studies on the role of statins as chemopreventive agents are warranted. äStatin use is Associated With Reduced Risk of Colorectal Cancer in Pat(epmc).pdf DeepDyve Pubget Overpricing