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10.3109/10409238.2014.884535 http://scihub22266oqcxt.onion/10.3109/10409238.2014.884535 C4912837!4912837!24524620     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Rev+Biochem+Mol+Biol 2014 ; 49 (2): 140-63 Nephropedia Template TP {{tp|p=24524620|t=2014. Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology |pdf=|usr=}}{{24524620}} gab.com Text Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24524620 #FOAvip O-linked ?-N-acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification of intracellular proteins. The dynamic and inducible cycling of the modification is governed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in response to UDP-GlcNAc levels in the hexosamine biosynthetic pathway (HBP). Due to its reliance on glucose flux and substrate availability, a major focus in the field has been on how O-GlcNAc contributes to metabolic disease. For years this post-translational modification has been known to modify thousands of proteins implicated in various disorders, but direct functional connections have until recently remained elusive. New research is beginning to reveal the specific mechanisms through which O-GlcNAc influences cell dynamics and disease pathology including clear examples of O-GlcNAc modification at a specific site on a given protein altering its biological functions. The following review intends to focus primarily on studies in the last half decade linking O-GlcNAc modification of proteins with chromatin-directed gene regulation, developmental processes, and several metabolically related disorders including Alzheimer?s, heart disease and cancer. These studies illustrate the emerging importance of this post-translational modification in biological processes and multiple pathophysiologies. Twit Text FOAVip Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=24524620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24524620 #FOAvip English Wikipedia <ref>{{Cite pmid|24524620}}</ref> Functional O-GlcNAc modifications: Implications in molecular regulation and pathophysiology #MMPMID24524620 Vaidyanathan K; Durning S; Wells L Crit Rev Biochem Mol Biol 2014[Mar]; 49 (2): 140-63 PMID24524620show ga O-linked ?-N-acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification of intracellular proteins. The dynamic and inducible cycling of the modification is governed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) in response to UDP-GlcNAc levels in the hexosamine biosynthetic pathway (HBP). Due to its reliance on glucose flux and substrate availability, a major focus in the field has been on how O-GlcNAc contributes to metabolic disease. For years this post-translational modification has been known to modify thousands of proteins implicated in various disorders, but direct functional connections have until recently remained elusive. New research is beginning to reveal the specific mechanisms through which O-GlcNAc influences cell dynamics and disease pathology including clear examples of O-GlcNAc modification at a specific site on a given protein altering its biological functions. The following review intends to focus primarily on studies in the last half decade linking O-GlcNAc modification of proteins with chromatin-directed gene regulation, developmental processes, and several metabolically related disorders including Alzheimer?s, heart disease and cancer. These studies illustrate the emerging importance of this post-translational modification in biological processes and multiple pathophysiologies. äFunctional O-GlcNAc modifications: Implications in molecular regulatio(epmc).pdf DeepDyve Pubget Overpricing