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10.1016/j.cell.2016.04.049 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.04.049 C4912690!4912690!27212238     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (7): 1658-71 Nephropedia Template TP {{tp|p=27212238|t=2016. Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response |pdf=|usr=}}{{27212238}} gab.com Text Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27212238 #FOAvip Macrophages are multifunctional cells that perform diverse roles in health and disease. Emerging evidence has suggested that these innate immune cells might also be capable of developing immunological memory, a trait previously associated with the adaptive system alone. While recent studies have focused on the dramatic macrophage reprogramming that follows infection and protects against secondary microbial attack, can macrophages also develop memory in response to other cues? Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential primer for their inflammatory response to tissue damage and infection in vivo. Priming is triggered via calcium-induced JNK signaling, which leads to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell to rapidly respond to subsequent injury or infection. This remarkable plasticity and capacity for memory places macrophages as key therapeutic targets for treatment of inflammatory disorders. Twit Text FOAVip Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27212238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27212238 #FOAvip English Wikipedia <ref>{{Cite pmid|27212238}}</ref> Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response #MMPMID27212238 Weavers H; Evans I; Martin P; Wood W Cell 2016[Jun]; 165 (7): 1658-71 PMID27212238show ga Macrophages are multifunctional cells that perform diverse roles in health and disease. Emerging evidence has suggested that these innate immune cells might also be capable of developing immunological memory, a trait previously associated with the adaptive system alone. While recent studies have focused on the dramatic macrophage reprogramming that follows infection and protects against secondary microbial attack, can macrophages also develop memory in response to other cues? Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential primer for their inflammatory response to tissue damage and infection in vivo. Priming is triggered via calcium-induced JNK signaling, which leads to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell to rapidly respond to subsequent injury or infection. This remarkable plasticity and capacity for memory places macrophages as key therapeutic targets for treatment of inflammatory disorders. äCorpse Engulfment Generates a Molecular Memory that Primes the Macroph(epmc).pdf DeepDyve Pubget Overpricing