Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27304918
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Stem+Cell+Reports
2016 ; 6
(6
): 957-969
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Boosting Hematopoietic Engraftment after in Utero Transplantation through
Vascular Niche Manipulation
#MMPMID27304918
Mokhtari S
; Colletti EJ
; Atala A
; Zanjani ED
; Porada CD
; Almeida-Porada G
Stem Cell Reports
2016[Jun]; 6
(6
): 957-969
PMID27304918
show ga
In utero hematopoietic stem/progenitor cell transplantation (IUHSCT) has only
been fully successful in the treatment of congenital immunodeficiency diseases.
Using sheep as a large animal model of IUHSCT, we demonstrate that administration
of CD146(+)CXCL12(+)VEGFR2(+) or CD146(+)CXCL12(+)VEGFR2(-) cells prior to, or in
combination with, hematopoietic stem/progenitor cells (HSC), results in robust
CXCL12 production within the fetal marrow environment, and significantly
increases the levels of hematopoietic engraftment. While in the fetal recipient,
donor-derived HSC were found to reside within the trabecular bone, the increased
expression of VEGFR2 in the microvasculature of CD146(+)CXCL12(+)VEGFR2(+)
transplanted animals enhanced levels of donor-derived hematopoietic cells in
circulation. These studies provide important insights into IUHSCT biology, and
demonstrate the feasibility of enhancing HSC engraftment to levels that would
likely be therapeutic in many candidate diseases for IUHSCT.