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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2015 ; 94
(45
): e1773
Nephropedia Template TP
gab.com Text
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English Wikipedia
Enterohepatic Helicobacter Species as a Potential Causative Factor in
Inflammatory Bowel Disease: A Meta-Analysis
#MMPMID26559250
Yu Q
; Zhang S
; Li L
; Xiong L
; Chao K
; Zhong B
; Li Y
; Wang H
; Chen M
Medicine (Baltimore)
2015[Nov]; 94
(45
): e1773
PMID26559250
show ga
The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H
pylori) and enterohepatic Helicobacter species (EHS), which can colonize the
intestinal mucosa. However, it is unclear whether EHS are associated with
inflammatory bowel disease (IBD). Therefore, we conducted this meta-analysis to
examine the association between EHS and IBD.PubMed, Scopus, Cochrane Library, and
Web of Science databases, as well as abstracts from conference proceedings were
searched to identify studies that used polymerase chain reaction to detect
Helicobacter species in intestinal samples from patients with IBD.After
screening, we carefully reviewed 20 of the 2955 identified studies, and performed
a meta-analysis of the findings from 14 studies (11 adult studies and 3 pediatric
studies) using STATA v12.0. These studies evaluated 1407 individuals, including
433 patients with Crohn's disease, 306 patients with ulcerative colitis, and 668
controls. The prevalence of Helicobacter species was higher among the patients
with IBD, compared to that among the controls, which corresponded to a pooled
risk ratio (RR) of 1.59 (95% confidence interval [CI]: 1.12-2.27). The RRs for
adult and pediatric patients with IBD were 1.61 (95% CI: 1.03-2.52) and 1.76 (95%
CI: 1.17-2.64), respectively. Compared to the controls, the patients with IBD
tended to have a higher prevalence of EHS in the intestinal mucosa (RR: 2.01, 95%
CI: 1.36-2.98), although the prevalence of H pylori was not significantly higher
(RR: 1.22, 95% CI: 0.77-1.95). Compared to the controls, the RRs for EHS in
patients with Crohn's disease and ulcerative colitis were 1.72 (95% CI:
1.20-2.47) and 3.27 (95% CI: 0.93-11.44), respectively.It appears that EHS was
associated with IBD, while intestinal H pylori infection was not significantly
associated with IBD. Further studies are needed to determine the involvement of
EHS in the microbiological etiology of IBD.