Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1097/BOR.0b013e328363eb08 http://scihub22266oqcxt.onion/10.1097/BOR.0b013e328363eb08 C4912130!4912130 !23917160     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23917160 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Rheumatol 2013 ; 25 (5 ): 658-64 Nephropedia Template TP {{tp|p=23917160 |t=2013. Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers |pdf=|usr=}}{{23917160 }} gab.com Text Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers JO: Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=23917160 #FOAvip PURPOSE OF REVIEW: To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS: Ongoing research in murine, canine and human models of sterile bone inflammation has solidified the hypothesis that sterile bone inflammation can be genetically driven. Mutations in Pstpip2, LPIN2 and IL1RN have been identified in monogenic autoinflammatory bone disorders that have allowed more detailed dissection of the immunologic defects that can produce sterile osteomyelitis. Recent studies in murine chronic multifocal osteomyelitis, deficiency of the interleukin-1 receptor antagonist (DIRA), Majeed syndrome and SAPHO syndrome reveal abnormalities in innate immune system function. IL-1 pathway dysregulation is present in several of these disorders and blocking IL-1 therapeutically has resulted in control of disease in DIRA, Majeed syndrome and in some cases of SAPHO and CRMO. Basic research demonstrates the importance of the innate immune system in disease pathogenesis and offers clues about potential disease triggers. SUMMARY: Research and clinical data produced over the last several years support the important role of innate immunity in sterile osteomyelitis. Based on what has been learned in the monogenic autoinflammatory bone disorders, IL-1 is emerging as an important pathway in the development of sterile bone inflammation. Twit Text FOAVip Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers ????Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=23917160 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23917160 #FOAvip English Wikipedia <ref>{{Cite pmid|23917160 }}</ref> Autoinflammatory bone disorders: update on immunologic abnormalities and clues about possible triggers #MMPMID23917160 Sharma M ; Ferguson PJ Curr Opin Rheumatol 2013[Sep]; 25 (5 ): 658-64 PMID23917160 show ga PURPOSE OF REVIEW: To provide an update on the genetics and immunologic basis of autoinflammatory bone disorders including chronic recurrent multifocal osteomyelitis including the monogenic forms of the disease. RECENT FINDINGS: Ongoing research in murine, canine and human models of sterile bone inflammation has solidified the hypothesis that sterile bone inflammation can be genetically driven. Mutations in Pstpip2, LPIN2 and IL1RN have been identified in monogenic autoinflammatory bone disorders that have allowed more detailed dissection of the immunologic defects that can produce sterile osteomyelitis. Recent studies in murine chronic multifocal osteomyelitis, deficiency of the interleukin-1 receptor antagonist (DIRA), Majeed syndrome and SAPHO syndrome reveal abnormalities in innate immune system function. IL-1 pathway dysregulation is present in several of these disorders and blocking IL-1 therapeutically has resulted in control of disease in DIRA, Majeed syndrome and in some cases of SAPHO and CRMO. Basic research demonstrates the importance of the innate immune system in disease pathogenesis and offers clues about potential disease triggers. SUMMARY: Research and clinical data produced over the last several years support the important role of innate immunity in sterile osteomyelitis. Based on what has been learned in the monogenic autoinflammatory bone disorders, IL-1 is emerging as an important pathway in the development of sterile bone inflammation. |Acquired Hyperostosis Syndrome/microbiology [MESH] |Anemia, Dyserythropoietic, Congenital/drug therapy/etiology/genetics/immunology [MESH] |Animals [MESH] |Chronic Disease [MESH] |Disease Models, Animal [MESH] |Dogs [MESH] |Gram-Positive Bacterial Infections/complications [MESH] |Hereditary Autoinflammatory Diseases/genetics/*immunology [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Immunologic Deficiency Syndromes [MESH] |Interleukin-1/antagonists & inhibitors [MESH] |Mice [MESH] |Osteomyelitis/drug therapy/etiology/genetics/*immunology [MESH] |Propionibacterium acnes [MESH] |Recurrence [MESH]Autoinflammatory bone disorders: update on immunologic abnormalities a(epmc).pdf DeepDyve Pubget Overpricing