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10.1007/s40610-016-0032-8 http://scihub22266oqcxt.onion/10.1007/s40610-016-0032-8 C4912015!4912015!27326387     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Mol+Biol+Rep 2016 ; 2 (1): 36-47 Nephropedia Template TP {{tp|p=27326387|t=2016. Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex |pdf=|usr=}}{{27326387}} gab.com Text Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex JO: Curr Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27326387 #FOAvip Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, are emerging as an integrated dynamic signaling platform to regulate MSC mechanobiology. This dynamic interconnectivity affects mechanical signaling and transfer of signals into the nucleus. In this way, nuclear and LINC-mediated cytoskeletal connectivity play a critical role in maintaining mechanical signaling that affects MSC fate by serving as both mechanosensory and mechanoresponsive structures. We review disease and age related compromises of LINC complexes and nucleoskeleton that contribute to the etiology of musculoskeletal diseases. Finally we invite the idea that acquired dysfunctions of LINC might be a contributing factor to conditions such as aging, microgravity and osteoporosis and discuss potential mechanical strategies to modulate LINC connectivity to combat these conditions. Twit Text FOAVip Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex ????Curr Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=27326387 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27326387 #FOAvip English Wikipedia <ref>{{Cite pmid|27326387}}</ref> Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex #MMPMID27326387 Uzer G; Rubin CT; Rubin J Curr Mol Biol Rep 2016[Mar]; 2 (1): 36-47 PMID27326387show ga Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, are emerging as an integrated dynamic signaling platform to regulate MSC mechanobiology. This dynamic interconnectivity affects mechanical signaling and transfer of signals into the nucleus. In this way, nuclear and LINC-mediated cytoskeletal connectivity play a critical role in maintaining mechanical signaling that affects MSC fate by serving as both mechanosensory and mechanoresponsive structures. We review disease and age related compromises of LINC complexes and nucleoskeleton that contribute to the etiology of musculoskeletal diseases. Finally we invite the idea that acquired dysfunctions of LINC might be a contributing factor to conditions such as aging, microgravity and osteoporosis and discuss potential mechanical strategies to modulate LINC connectivity to combat these conditions. äCell Mechanosensitivity is Enabled by the LINC Nuclear Complex (epmc).pdf DeepDyve Pubget Overpricing