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10.1016/j.gde.2015.10.007 http://scihub22266oqcxt.onion/10.1016/j.gde.2015.10.007 C4911328!4911328!26706451     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Genet+Dev 2016 ; 37 (ä): 1-8 Nephropedia Template TP {{tp|p=26706451|t=2016. The redundancy of the mammalian heterochromatic compartment |pdf=|usr=}}{{26706451}} gab.com Text The redundancy of the mammalian heterochromatic compartment JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=26706451 #FOAvip Two chromatin compartments are present in most mammalian cells; the first contains primarily euchromatic, early replicating chromatin and the second, primarily late-replicating heterochromatin, which is the subject of this review. Heterochromatin is concentrated in three intranuclear regions: the nuclear periphery, the perinucleolar space and in pericentromeric bodies. We review recent evidence demonstrating that the heterochromatic compartment is critically involved in global nuclear organization and the maintenance of genome stability, and discuss models regarding how this compartment is formed and maintained. We also evaluate our understanding of how heterochromatic sequences (herein named heterochromatic associated regions (HADs)) might be tethered within these regions and review experiments that reveal the stochastic nature of individual HAD positioning within the compartment. These investigations suggest a substantial level of functional redundancy within the heterochromatic compartment. Twit Text FOAVip The redundancy of the mammalian heterochromatic compartment ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=26706451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26706451 #FOAvip English Wikipedia <ref>{{Cite pmid|26706451}}</ref> The redundancy of the mammalian heterochromatic compartment #MMPMID26706451 Ritland Politz JC; Scalzo D; Groudine M Curr Opin Genet Dev 2016[Apr]; 37 (ä): 1-8 PMID26706451show ga Two chromatin compartments are present in most mammalian cells; the first contains primarily euchromatic, early replicating chromatin and the second, primarily late-replicating heterochromatin, which is the subject of this review. Heterochromatin is concentrated in three intranuclear regions: the nuclear periphery, the perinucleolar space and in pericentromeric bodies. We review recent evidence demonstrating that the heterochromatic compartment is critically involved in global nuclear organization and the maintenance of genome stability, and discuss models regarding how this compartment is formed and maintained. We also evaluate our understanding of how heterochromatic sequences (herein named heterochromatic associated regions (HADs)) might be tethered within these regions and review experiments that reveal the stochastic nature of individual HAD positioning within the compartment. These investigations suggest a substantial level of functional redundancy within the heterochromatic compartment. äThe redundancy of the mammalian heterochromatic compartment (epmc).pdf DeepDyve Pubget Overpricing