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Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of
Intramembrane Aromatic Prenyltransferases
#MMPMID26922674
Li W
Trends Biochem Sci
2016[Apr]; 41
(4
): 356-370
PMID26922674
show ga
The UbiA superfamily of intramembrane prenyltransferases catalyzes a key
biosynthetic step in the production of ubiquinones, menaquinones, plastoquinones,
hemes, chlorophylls, vitamin E, and structural lipids. These lipophilic compounds
serve as electron and proton carriers for cellular respiration and
photosynthesis, as antioxidants to reduce cell damage, and as structural
components of microbial cell walls and membranes. This article reviews the
biological functions and enzymatic activities of representative members of the
superfamily, focusing on the remarkable recent research progress revealing that
the UbiA superfamily is centrally implicated in several important physiological
processes and human diseases. Because prenyltransferases in this superfamily have
distinctive substrate preferences, two recent crystal structures are compared to
illuminate the general mechanism for substrate recognition.
|Alkyl and Aryl Transferases/*chemistry/genetics/metabolism
[MESH]
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