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10.1080/15384047.2016.1156273 http://scihub22266oqcxt.onion/10.1080/15384047.2016.1156273 C4910909!4910909 !26987032     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26987032 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression |pdf=|usr=}}{{26987032 }} gab.com Text Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26987032 #FOAvip Metformin has been reported to inhibit the growth of various types of cancers, including prostate cancer. Yet the mode of anti-cancer action of metformin and the underlying mechanisms remain not fully elucidated. We hypothesized that the antitumorigenic effects of metformin are mediated through upregulation of pigment epithelium-derived factor (PEDF) expression in prostate cancer cells. In this report, metformin treatment significantly inhibited the proliferation and colony formation of prostate cancer cells, in a dose- and time-dependent manner. Meanwhile, Metformin markedly suppressed migration and invasion and induced apoptosis of both LNCaP and PC3 cancer cells. Metformin also reduced PC3 tumor growth in BALB/c nude mice in vivo. Furthermore, metformin treatment was associated with higher PEDF expression in both prostate cancer cells and tumor tissue. Taken together, metformin inhibits prostate cancer cell proliferation, migration, invasion and tumor growth, and these activities are mediated by upregulation of PEDF expression. These findings provide a novel insight into the molecular functions of metformin as an anticancer agent. Twit Text FOAVip Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26987032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26987032 #FOAvip English Wikipedia <ref>{{Cite pmid|26987032 }}</ref> Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression #MMPMID26987032 Chen X ; Li C ; He T ; Mao J ; Li C ; Lyu J ; Meng QH Cancer Biol Ther 2016[May]; 17 (5 ): 507-14 PMID26987032 show ga Metformin has been reported to inhibit the growth of various types of cancers, including prostate cancer. Yet the mode of anti-cancer action of metformin and the underlying mechanisms remain not fully elucidated. We hypothesized that the antitumorigenic effects of metformin are mediated through upregulation of pigment epithelium-derived factor (PEDF) expression in prostate cancer cells. In this report, metformin treatment significantly inhibited the proliferation and colony formation of prostate cancer cells, in a dose- and time-dependent manner. Meanwhile, Metformin markedly suppressed migration and invasion and induced apoptosis of both LNCaP and PC3 cancer cells. Metformin also reduced PC3 tumor growth in BALB/c nude mice in vivo. Furthermore, metformin treatment was associated with higher PEDF expression in both prostate cancer cells and tumor tissue. Taken together, metformin inhibits prostate cancer cell proliferation, migration, invasion and tumor growth, and these activities are mediated by upregulation of PEDF expression. These findings provide a novel insight into the molecular functions of metformin as an anticancer agent. |Cell Movement [MESH] |Cell Proliferation [MESH] |Eye Proteins/*metabolism [MESH] |Humans [MESH] |Hypoglycemic Agents/pharmacology/*therapeutic use [MESH] |Male [MESH] |Metformin/pharmacology/*therapeutic use [MESH] |Nerve Growth Factors/*metabolism [MESH] |Prostatic Neoplasms/*drug therapy/pathology [MESH] |Serpins/*metabolism [MESH]Metformin inhibits prostate cancer cell proliferation, migration, and (epmc).pdf DeepDyve Pubget Overpricing