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10.1016/j.jclinepi.2015.12.003

http://scihub22266oqcxt.onion/10.1016/j.jclinepi.2015.12.003
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suck abstract from ncbi


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pmid26718729
      J+Clin+Epidemiol 2016 ; 74 (ä): 57-65
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  • Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses #MMPMID26718729
  • Hussain JA ; White IR ; Langan D ; Johnson MJ ; Currow DC ; Torgerson DJ ; Bland M
  • J Clin Epidemiol 2016[Jun]; 74 (ä): 57-65 PMID26718729 show ga
  • OBJECTIVES: To assess the risk posed by missing data (MD) to the power and validity of trials evaluating palliative interventions. STUDY DESIGN AND SETTING: A systematic review of MD in published randomized controlled trials (RCTs) of palliative interventions in participants with life-limiting illnesses was conducted, and random-effects meta-analyses and metaregression were performed. CENTRAL, MEDLINE, and EMBASE (2009-2014) were searched with no language restrictions. RESULTS: One hundred and eight RCTs representing 15,560 patients were included. The weighted estimate for MD at the primary endpoint was 23.1% (95% confidence interval [CI] 19.3, 27.4). Larger MD proportions were associated with increasing numbers of questions/tests requested (odds ratio [OR], 1.19; 95% CI 1.05, 1.35) and with longer study duration (OR, 1.09; 95% CI 1.02, 1.17). Meta-analysis found evidence of differential rates of MD between trial arms, which varied in direction (OR, 1.04; 95% CI 0.90, 1.20; I(2) 35.9, P = 0.001). Despite randomization, MD in the intervention arms (vs. control) were more likely to be attributed to disease progression unrelated to the intervention (OR, 1.31; 95% CI 1.02, 1.69). This was not the case for MD due to death (OR, 0.92; 95% CI 0.78, 1.08). CONCLUSION: The overall proportion and differential rates and reasons for MD reduce the power and potentially introduce bias to palliative care trials.
  • |*Data Accuracy [MESH]
  • |*Data Interpretation, Statistical [MESH]
  • |Bias [MESH]
  • |Humans [MESH]
  • |Palliative Care/methods/*statistics & numerical data [MESH]
  • |Randomized Controlled Trials as Topic/methods/*statistics & numerical data [MESH]
  • |Reproducibility of Results [MESH]


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