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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Epidemiol
2016 ; 74
(ä): 57-65
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Missing data in randomized controlled trials testing palliative interventions
pose a significant risk of bias and loss of power: a systematic review and
meta-analyses
#MMPMID26718729
Hussain JA
; White IR
; Langan D
; Johnson MJ
; Currow DC
; Torgerson DJ
; Bland M
J Clin Epidemiol
2016[Jun]; 74
(ä): 57-65
PMID26718729
show ga
OBJECTIVES: To assess the risk posed by missing data (MD) to the power and
validity of trials evaluating palliative interventions. STUDY DESIGN AND SETTING:
A systematic review of MD in published randomized controlled trials (RCTs) of
palliative interventions in participants with life-limiting illnesses was
conducted, and random-effects meta-analyses and metaregression were performed.
CENTRAL, MEDLINE, and EMBASE (2009-2014) were searched with no language
restrictions. RESULTS: One hundred and eight RCTs representing 15,560 patients
were included. The weighted estimate for MD at the primary endpoint was 23.1%
(95% confidence interval [CI] 19.3, 27.4). Larger MD proportions were associated
with increasing numbers of questions/tests requested (odds ratio [OR], 1.19; 95%
CI 1.05, 1.35) and with longer study duration (OR, 1.09; 95% CI 1.02, 1.17).
Meta-analysis found evidence of differential rates of MD between trial arms,
which varied in direction (OR, 1.04; 95% CI 0.90, 1.20; I(2) 35.9, P = 0.001).
Despite randomization, MD in the intervention arms (vs. control) were more likely
to be attributed to disease progression unrelated to the intervention (OR, 1.31;
95% CI 1.02, 1.69). This was not the case for MD due to death (OR, 0.92; 95% CI
0.78, 1.08). CONCLUSION: The overall proportion and differential rates and
reasons for MD reduce the power and potentially introduce bias to palliative care
trials.
|*Data Accuracy
[MESH]
|*Data Interpretation, Statistical
[MESH]
|Bias
[MESH]
|Humans
[MESH]
|Palliative Care/methods/*statistics & numerical data
[MESH]
|Randomized Controlled Trials as Topic/methods/*statistics & numerical data
[MESH]