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10.1080/2162402X.2015.1118600

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suck abstract from ncbi


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pmid27467929
      Oncoimmunology 2016 ; 5 (5 ): e1118600
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  • Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1 #MMPMID27467929
  • Vacchelli E ; Ma Y ; Baracco EE ; Zitvogel L ; Kroemer G
  • Oncoimmunology 2016[May]; 5 (5 ): e1118600 PMID27467929 show ga
  • Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.
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