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10.7150/ijbs.14718 http://scihub22266oqcxt.onion/10.7150/ijbs.14718 C4910596!4910596 !27313491     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27313491 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Biol+Sci 2016 ; 12 (7 ): 768-75 Nephropedia Template TP {{tp|p=27313491 |t=2016. Inhibition of wnt/?-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide |pdf=|usr=}}{{27313491 }} gab.com Text Inhibition of wnt/ -catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27313491 #FOAvip Hepatocellular carcinoma (HCC) is one of the most common forms of malignant cancers in the world, yet very few effective systemic treatments for HCC patients exist. Thus, the development of new treatment modalities presents a great need. The wnt/?-catenin signaling pathway is highly activated in stem cell-like aggressive HCC, which is associated with chemoresistance and poor survival in HCC patients. In a previous study, we found that an FDA-approved psychiatric drug, pimozide (PMZ), has anti-cancer properties in HCC cell lines that express epithelial cell adhesion molecule (EpCAM), a hepatic stem cell marker that is a functional down-stream target of the wnt/?-catenin pathway. In this study, we demonstrate that PMZ effectively inhibits cell growth of HCC cells by disrupting the wnt/?-catenin signaling pathway and reducing EpCAM expression. Thus, PMZ may be a useful molecular entity that could be repurposed as an anti-cancer therapy for treatment of HCC. Twit Text FOAVip Inhibition of wnt/ -catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27313491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27313491 #FOAvip English Wikipedia <ref>{{Cite pmid|27313491 }}</ref> Inhibition of wnt/?-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide #MMPMID27313491 Fako V ; Yu Z ; Henrich CJ ; Ransom T ; Budhu AS ; Wang XW Int J Biol Sci 2016[]; 12 (7 ): 768-75 PMID27313491 show ga Hepatocellular carcinoma (HCC) is one of the most common forms of malignant cancers in the world, yet very few effective systemic treatments for HCC patients exist. Thus, the development of new treatment modalities presents a great need. The wnt/?-catenin signaling pathway is highly activated in stem cell-like aggressive HCC, which is associated with chemoresistance and poor survival in HCC patients. In a previous study, we found that an FDA-approved psychiatric drug, pimozide (PMZ), has anti-cancer properties in HCC cell lines that express epithelial cell adhesion molecule (EpCAM), a hepatic stem cell marker that is a functional down-stream target of the wnt/?-catenin pathway. In this study, we demonstrate that PMZ effectively inhibits cell growth of HCC cells by disrupting the wnt/?-catenin signaling pathway and reducing EpCAM expression. Thus, PMZ may be a useful molecular entity that could be repurposed as an anti-cancer therapy for treatment of HCC. |Antipsychotic Agents/*pharmacology [MESH] |Apoptosis/drug effects [MESH] |Carcinoma, Hepatocellular/*metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Epithelial Cell Adhesion Molecule/metabolism [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Liver Neoplasms/*metabolism [MESH] |Pimozide/*pharmacology [MESH] |Signal Transduction/drug effects [MESH] |Wnt Proteins/*metabolism [MESH]Inhibition of wnt/?-catenin Signaling in Hepatocellular Carcinoma by a(epmc).pdf DeepDyve Pubget Overpricing