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2016 ; 7
(8
): 965-72
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gab.com Text
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English Wikipedia
Association between Perioperative Blood Transfusion and Oncologic Outcomes after
Curative Surgery for Renal Cell Carcinoma
#MMPMID27313787
Park YH
; Kim YJ
; Kang SH
; Kim HH
; Byun SS
; Lee JY
; Hong SH
J Cancer
2016[]; 7
(8
): 965-72
PMID27313787
show ga
PURPOSE: We aimed to elucidate the association between perioperative blood
transfusion (PBT) and the prognosis of patients undergoing curative surgery for
renal cell carcinoma (RCC). METHODS: In all, 3,832 patients with RCC who had
undergone curative surgery were included in this study from a multicenter
database. PBT was defined as the transfusion of packed red blood cells within
seven days before surgery, during surgery, or within the postoperative
hospitalization period. The association of PBT with oncologic outcomes was
evaluated using univariate and multivariate Cox regression analyses, and
regression adjustment with propensity score matching. RESULTS: Overall, 11.7%
(447/3,832) of patients received PBT. Patients receiving PBT were significantly
older at diagnosis, and had lower BMI, higher comorbidities, worse ECOG
performance status, and more initial symptoms. Moreover, higher pathologic TNM
stage, larger mass size, higher nuclear grade, more sarcomatoid differentiation,
and more tumor necrosis were all observed more frequently in patients who
received PBT. In univariate analysis, relapse-free survival, cancer-specific
survival, and overall survival rates were worse in patients who received PBT;
however, these factors became insignificant in the matched pairs after propensity
score matching. On multivariate Cox regression analysis and regression adjustment
with propensity score matching, significant prognostic effects of PBT on disease
relapse, cancer-specific mortality, and all-cause mortality were not observed.
CONCLUSIONS: This multicenter database analysis demonstrates no significant
prognostic association between PBT and oncologic outcomes in patients with RCC.