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Opposing effects of cat and dog ownership and allergic sensitization on eczema in
an atopic birth cohort
#MMPMID20884006
Epstein TG
; Bernstein DI
; Levin L
; Khurana Hershey GK
; Ryan PH
; Reponen T
; Villareal M
; Lockey JE
; Lemasters GK
J Pediatr
2011[Feb]; 158
(2
): 265-71.e1-5
PMID20884006
show ga
OBJECTIVE: To examine risk factors for eczema at age 4 years. STUDY DESIGN:
Beginning at 1 year of age, infants of atopic parents (n = 636) had annual
clinical evaluations and skin prick tests (SPTs) to 15 aeroallergens and milk and
egg. Parents completed validated surveys on eczema and environmental exposures.
House dust samples were evaluated for allergens and endotoxin. Eczema was defined
as a parental report of scratching, and redness, "raised bumps," or dry
skin/scaling for 6 of the last 12 months. RESULTS: At age 4 years, a total of 90
children (14%) had eczema. Not having a dog before 1 year of age and being dog
SPT+ at 1, 2, or 3 years of age conferred a 4-fold higher risk for eczema at age
4 years (adjusted odds ratio [aOR] = 3.9 [1.6-9.2]; P = .002). Among dog owners,
however, dog SPT+ was not associated with significantly increased risk (aOR 1.3
[0.3-6.8]; P = .8). Among children with cats before 1 year of age, cat SPT+
conferred significantly increased risk for eczema (aOR = 13.3 [3.1-57.9]; P <
.001). Among non-cat owners, cat SPT+ was not associated with increased risk (aOR
= 1.1 [0.5-2.7]; P = .8). CONCLUSION: Dog ownership significantly reduced the
risk for eczema at age 4 years among dog-sensitized children, cat ownership
combined with cat sensitization significantly increased the risk.
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