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10.1016/j.celrep.2016.05.035 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.05.035 C4909568!4909568!27264180     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (11): 2367-76 Nephropedia Template TP {{tp|p=27264180|t=2016. Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow |pdf=|usr=}}{{27264180}} gab.com Text Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27264180 #FOAvip Anti-metabolite agents that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used anti-metabolite therapeutic with varying efficacy, induces specific alterations to nucleotide metabolism by disrupting pyrimidine homeostasis. An integrative metabolomics analysis of the cellular response to 5-FU shows intracellular uracil accumulation, while deoxyuridine levels exhibited increased flux into the extracellular space resulting in an induction of overflow metabolism. Subsequent analysis from mice bearing colorectal tumors treated with 5-FU, show specific secretion of metabolites in tumor-bearing mice into serum that results from alterations in nucleotide flux and reduction in overflow metabolism. Together these findings identify a determinant of an anti-metabolite response that may be exploited to more precisely define the tumors that could respond to targeting cancer metabolism. Twit Text FOAVip Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27264180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27264180 #FOAvip English Wikipedia <ref>{{Cite pmid|27264180}}</ref> Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow #MMPMID27264180 Ser Z; Gao X; Johnson C; Mehrmohamadi M; Liu X; Li S; Locasale JW Cell Rep 2016[Jun]; 15 (11): 2367-76 PMID27264180show ga Anti-metabolite agents that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used anti-metabolite therapeutic with varying efficacy, induces specific alterations to nucleotide metabolism by disrupting pyrimidine homeostasis. An integrative metabolomics analysis of the cellular response to 5-FU shows intracellular uracil accumulation, while deoxyuridine levels exhibited increased flux into the extracellular space resulting in an induction of overflow metabolism. Subsequent analysis from mice bearing colorectal tumors treated with 5-FU, show specific secretion of metabolites in tumor-bearing mice into serum that results from alterations in nucleotide flux and reduction in overflow metabolism. Together these findings identify a determinant of an anti-metabolite response that may be exploited to more precisely define the tumors that could respond to targeting cancer metabolism. äTargeting one carbon metabolism with an antimetabolite disrupts pyrimi(epmc).pdf DeepDyve Pubget Overpricing