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10.1080/23723556.2016.1167158

http://scihub22266oqcxt.onion/10.1080/23723556.2016.1167158
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C4909411!4909411!27314101
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suck abstract from ncbi


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pmid27314101      Mol+Cell+Oncol 2016 ; 3 (3): ä
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  • ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability #MMPMID27314101
  • Koschmann C; Lowenstein PR; Castro MG
  • Mol Cell Oncol 2016[May]; 3 (3): ä PMID27314101show ga
  • Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is mutated in nearly a third of pediatric glioblastoma (GBM) patients. We developed an animal model of ATRX-deficient GBM. Using this model combined with analysis of multiple human glioma genome-wide datasets, we determined that ATRX mutation leads to genetic instability, impaired non-homologous end joining, and alternate lengthening of telomeres (ALT).
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