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10.1016/j.celrep.2016.04.051 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.051 C4909264!4909264!27184845     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (8): 1615-23 Nephropedia Template TP {{tp|p=27184845|t=2016. PDK1 is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division |pdf=|usr=}}{{27184845}} gab.com Text PDK1 is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium. Production of phosphatidylinositol triphosphate (PIP3) is localized to the apical side of basal cells. Asymmetric recruitment of atypical protein kinase C (aPKC), and partitioning defective (PAR) 3, are impaired in PDK1 conditional knockout (CKO) epidermis. PDK1CKO keratinocytes do not undergo calcium-induced activation of aPKC or IGF1-induced activation of AKT and fail to differentiate. PDK1CKO epidermis shows decreased expression of Notch, a downstream effector of ACD, and restoration of Notch rescues defective expression of differentiation-induced Notch targets in vitro. We therefore propose that PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of ACD and the Notch-dependent differentiation program. Twit Text FOAVip PDK1 is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip English Wikipedia <ref>{{Cite pmid|27184845}}</ref> PDK1 is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division #MMPMID27184845 Dainichi T; Hayden MS; Park SG; Oh H; Seeley JJ; Grinberg-Bleyer Y; Beck KM; Miyachi Y; Kabashima K; Hashimoto T; Ghosh S Cell Rep 2016[May]; 15 (8): 1615-23 PMID27184845show ga Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium. Production of phosphatidylinositol triphosphate (PIP3) is localized to the apical side of basal cells. Asymmetric recruitment of atypical protein kinase C (aPKC), and partitioning defective (PAR) 3, are impaired in PDK1 conditional knockout (CKO) epidermis. PDK1CKO keratinocytes do not undergo calcium-induced activation of aPKC or IGF1-induced activation of AKT and fail to differentiate. PDK1CKO epidermis shows decreased expression of Notch, a downstream effector of ACD, and restoration of Notch rescues defective expression of differentiation-induced Notch targets in vitro. We therefore propose that PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of ACD and the Notch-dependent differentiation program. äPDK1 is a Regulator of Epidermal Differentiation that Activates and Or(epmc).pdf DeepDyve Pubget Overpricing