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10.1016/j.celrep.2016.04.051 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.051 C4909264!4909264 !27184845     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27184845 &cmd=llinks): Failed to open stream: HTTP request failed! 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PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division |pdf=|usr=}}{{27184845 }} gab.com Text PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here, we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium. Production of phosphatidyl inositol triphosphate (PIP3) is localized to the apical side of basal cells. Asymmetric recruitment of atypical protein kinase C (aPKC) and partitioning defective (PAR) 3 is impaired in PDK1 conditional knockout (CKO) epidermis. PDK1(CKO) keratinocytes do not undergo calcium-induced activation of aPKC or IGF1-induced activation of AKT and fail to differentiate. PDK1(CKO) epidermis shows decreased expression of Notch, a downstream effector of ACD, and restoration of Notch rescues defective expression of differentiation-induced Notch targets in vitro. We therefore propose that PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of ACD and the Notch-dependent differentiation program. Twit Text FOAVip PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27184845 #FOAvip English Wikipedia <ref>{{Cite pmid|27184845 }}</ref> PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division #MMPMID27184845 Dainichi T ; Hayden MS ; Park SG ; Oh H ; Seeley JJ ; Grinberg-Bleyer Y ; Beck KM ; Miyachi Y ; Kabashima K ; Hashimoto T ; Ghosh S Cell Rep 2016[May]; 15 (8 ): 1615-23 PMID27184845 show ga Asymmetric cell division (ACD) in a perpendicular orientation promotes cell differentiation and organizes the stratified epithelium. However, the upstream cues regulating ACD have not been identified. Here, we report that phosphoinositide-dependent kinase 1 (PDK1) plays a critical role in establishing ACD in the epithelium. Production of phosphatidyl inositol triphosphate (PIP3) is localized to the apical side of basal cells. Asymmetric recruitment of atypical protein kinase C (aPKC) and partitioning defective (PAR) 3 is impaired in PDK1 conditional knockout (CKO) epidermis. PDK1(CKO) keratinocytes do not undergo calcium-induced activation of aPKC or IGF1-induced activation of AKT and fail to differentiate. PDK1(CKO) epidermis shows decreased expression of Notch, a downstream effector of ACD, and restoration of Notch rescues defective expression of differentiation-induced Notch targets in vitro. We therefore propose that PDK1 signaling regulates the basal-to-suprabasal switch in developing epidermis by acting as both an activator and organizer of ACD and the Notch-dependent differentiation program. |*Asymmetric Cell Division [MESH] |*Cell Differentiation [MESH] |*Epidermal Cells [MESH] |3-Phosphoinositide-Dependent Protein Kinases/*metabolism [MESH] |Animals [MESH] |Calcium/pharmacology [MESH] |Cells, Cultured [MESH] |Embryo, Mammalian/cytology/enzymology [MESH] |Epidermis/*enzymology [MESH] |Keratinocytes/cytology/drug effects/metabolism [MESH] |Mice, Knockout [MESH] |Phenotype [MESH] |Phosphatidylinositols/metabolism [MESH] |Phosphorylation/drug effects [MESH] |Protein Kinase C [MESH] |Receptors, Notch/metabolism [MESH]PDK1 Is a Regulator of Epidermal Differentiation that Activates and Or(epmc).pdf DeepDyve Pubget Overpricing