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10.2215/CJN.08091109

http://scihub22266oqcxt.onion/10.2215/CJN.08091109
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C4909119!4909119!20056758
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suck abstract from ncbi


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pmid20056758      Clin+J+Am+Soc+Nephrol 2010 ; 5 (2): 365-70
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  • Assessment of Renal Pathology and Dysfunction in Pediatric Patients with Fabry Disease #MMPMID20056758
  • Ramaswami U; Najafian B; Schieppati A; Mauer M; Bichet DG
  • Clin J Am Soc Nephrol 2010[Feb]; 5 (2): 365-70 PMID20056758show ga
  • Overt renal disease often first presents in males with Fabry disease in early-to-mid adulthood, but proteinuria and reduced glomerular filtration rate may occur in adolescents and in young children. More recently, kidney biopsy data have shown early renal histological changes in pediatric patients. Renal investigations and their timing in children remain poorly defined. A consensus on renal investigations is necessary to understand the natural progression of the disease and to evaluate the efficacy of treatments such as enzyme replacement therapies. This manuscript addresses three main categories, including the use of glomerular filtration rates, measuring albuminuria and renal biopsies in children.
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