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2016 ; 6
(6
): e010269
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Interventions for Menière s disease: protocol for an umbrella systematic review
and a network meta-analysis
#MMPMID27288370
van Esch BF
; van der Zaag-Loonen HJ
; Bruintjes TD
; van Benthem PP
BMJ Open
2016[Jun]; 6
(6
): e010269
PMID27288370
show ga
INTRODUCTION: The large number of treatment modalities for patients diagnosed
with Menière's disease (MD) complicates the selection of the best available
treatment as the comparative efficacy of these interventions is not clear. We aim
to identify the treatment or treatments with the highest efficacy of current
pharmacological and non-pharmacological treatments for MD. METHODS AND ANALYSIS:
We will identify all available systematic reviews on the treatment of MD. An
online database search will be conducted in association with the UK Cochrane
Centre, particularly the Ear, Nose and Throat Group. We will screen the
systematic reviews for eligible randomised controlled trials (RCTs) to execute a
network meta-analysis. In addition, online databases will be checked for eligible
RCTs on treatments that were published after the latest systematic search was
conducted. The characteristics of each RCT will be summarised, including the
general design, the participants, the interventions, the outcome measurements,
the duration of therapy and adverse events. The risk of bias will be assessed by
means of the Cochrane Collaboration's risk of bias tool. The included studies
will be assessed for methodological and statistical heterogeneity; the latter
will be quantified by means of the I(2) statistic. The primary outcome will be
the efficacy of treatment in terms of control of vertigo attacks. Secondary
outcome measures will be the loss or improvement of hearing, severity of vertigo
attacks and tinnitus, perception of aural fullness, quality of life, and the
incidence of adverse events and complications. ETHICS AND DISSEMINATION: Formal
ethical approval is not required as primary data will not be collected. The
review will be disseminated in peer-reviewed publications and conference
presentations. PROSPERO REGISTRATION NUMBER: CRD42015024243.