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10.1186/s13075-016-1037-7 http://scihub22266oqcxt.onion/10.1186/s13075-016-1037-7 C4908726!4908726!27301320     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Res+Ther 2016 ; 18 (ä): ä Nephropedia Template TP {{tp|p=27301320|t=2016. Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis |pdf=|usr=}}{{27301320}} gab.com Text Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip Background: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. Methods: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Results: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naïve mice ameliorated the development of CII-induced arthritis. Conclusion: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance. Electronic supplementary material: The online version of this article (doi:10.1186/s13075-016-1037-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip English Wikipedia <ref>{{Cite pmid|27301320}}</ref> Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis #MMPMID27301320 Andersson SEM; Eneljung T; Tengvall S; Jirholt P; Stern A; Henningsson L; Liang B; Thorarinsdottir K; Kihlberg J; Holmdahl R; Mårtensson IL; Gustafsson K; Gjertsson I Arthritis Res Ther 2016[]; 18 (ä): ä PMID27301320show ga Background: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. Methods: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. Results: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naïve mice ameliorated the development of CII-induced arthritis. Conclusion: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance. Electronic supplementary material: The online version of this article (doi:10.1186/s13075-016-1037-7) contains supplementary material, which is available to authorized users. äCollagen epitope expression on B cells is sufficient to confer toleran(epmc).pdf DeepDyve Pubget Overpricing