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10.1186/s13075-016-1037-7 http://scihub22266oqcxt.onion/10.1186/s13075-016-1037-7 C4908726!4908726 !27301320     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27301320 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Arthritis+Res+Ther 2016 ; 18 (1 ): 140 Nephropedia Template TP {{tp|p=27301320 |t=2016. Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis |pdf=|usr=}}{{27301320 }} gab.com Text Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip BACKGROUND: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. METHODS: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. RESULTS: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naïve mice ameliorated the development of CII-induced arthritis. CONCLUSION: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance. Twit Text FOAVip Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27301320 #FOAvip English Wikipedia <ref>{{Cite pmid|27301320 }}</ref> Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis #MMPMID27301320 Andersson SE ; Eneljung T ; Tengvall S ; Jirholt P ; Stern A ; Henningsson L ; Liang B ; Thorarinsdottir K ; Kihlberg J ; Holmdahl R ; Mårtensson IL ; Gustafsson K ; Gjertsson I Arthritis Res Ther 2016[Jun]; 18 (1 ): 140 PMID27301320 show ga BACKGROUND: The mechanisms underlying tolerance induction and maintenance in autoimmune arthritis remain elusive. In a mouse model of rheumatoid arthritis, collagen type II (CII)-induced arthritis, we explore the contribution of B cells to antigen-specific tolerance. METHODS: To generate expression of the CII-peptide specifically on B-cell major histocompatibility complex type II, lentiviral-based gene therapy including a B-cell-specific Igk promoter was used. RESULTS: Presentation of the CII-peptide on B cells significantly reduced the frequency and severity of arthritis as well as the serum levels of CII -specific IgG antibodies. Further, both frequency and suppressive function of regulatory T cells were increased in tolerized mice. Adoptive transfer of regulatory T cells from tolerized mice to naïve mice ameliorated the development of CII-induced arthritis. CONCLUSION: Our data suggest that endogenous presentation of the CII-peptide on B cells is one of the key contributors to arthritis tolerance induction and maintenance. |Adoptive Transfer [MESH] |Animals [MESH] |Antigen Presentation/immunology [MESH] |Arthritis, Experimental/*immunology [MESH] |Arthritis, Rheumatoid/*immunology [MESH] |B-Lymphocytes/*immunology [MESH] |Collagen Type II/*immunology [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epitopes, T-Lymphocyte/immunology [MESH] |Flow Cytometry [MESH] |Fluorescent Antibody Technique [MESH] |Immune Tolerance/*immunology [MESH] |Immunodominant Epitopes/immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Male [MESH] |Mice [MESH]Collagen epitope expression on B cells is sufficient to confer toleran(epmc).pdf DeepDyve Pubget Overpricing