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10.1038/srep28066 http://scihub22266oqcxt.onion/10.1038/srep28066 C4908659!4908659 !27301852     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27301852 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 28066 Nephropedia Template TP {{tp|p=27301852 |t=2016. IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway |pdf=|usr=}}{{27301852 }} gab.com Text IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27301852 #FOAvip Injury of renal tubular epithelial cells can induce acute renal failure and obstructive nephropathy. Previous studies have shown that administration of insulin-like growth factor-1 (IGF-1) ameliorates the renal injury in a mouse unilateral ureteral obstruction (UUO) model, whereas the underlying mechanisms are not completely understood. Here, we addressed this question. We found that the administration of IGF-1 significantly reduced the severity of the renal fibrosis in UUO. By analyzing purified renal epithelial cells, we found that IGF-1 significantly reduced the apoptotic cell death of renal epithelial cells, seemingly through upregulation of anti-apoptotic protein Bcl-2, at protein but not mRNA level. Bioinformatics analyses and luciferase-reporter assay showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its protein translation in renal epithelial cells. Moreover, IGF-1 suppressed miR-429 to increase Bcl-2 in renal epithelial cells to improve survival after UUO. Furthermore, inhibition of ERK/MAPK signaling pathway in renal epithelial cells abolished the suppressive effects of IGF-1 on miR-429 activation, and then the enhanced effects on Bcl-2 in UUO. Thus, our data suggest that IGF-1 may protect renal tubular epithelial cells via activation of ERK/MAPK signaling pathway during renal injury. Twit Text FOAVip IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27301852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27301852 #FOAvip English Wikipedia <ref>{{Cite pmid|27301852 }}</ref> IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway #MMPMID27301852 Wu Z ; Yu Y ; Niu L ; Fei A ; Pan S Sci Rep 2016[Jun]; 6 (ä): 28066 PMID27301852 show ga Injury of renal tubular epithelial cells can induce acute renal failure and obstructive nephropathy. Previous studies have shown that administration of insulin-like growth factor-1 (IGF-1) ameliorates the renal injury in a mouse unilateral ureteral obstruction (UUO) model, whereas the underlying mechanisms are not completely understood. Here, we addressed this question. We found that the administration of IGF-1 significantly reduced the severity of the renal fibrosis in UUO. By analyzing purified renal epithelial cells, we found that IGF-1 significantly reduced the apoptotic cell death of renal epithelial cells, seemingly through upregulation of anti-apoptotic protein Bcl-2, at protein but not mRNA level. Bioinformatics analyses and luciferase-reporter assay showed that miR-429 targeted the 3'-UTR of Bcl-2 mRNA to inhibit its protein translation in renal epithelial cells. Moreover, IGF-1 suppressed miR-429 to increase Bcl-2 in renal epithelial cells to improve survival after UUO. Furthermore, inhibition of ERK/MAPK signaling pathway in renal epithelial cells abolished the suppressive effects of IGF-1 on miR-429 activation, and then the enhanced effects on Bcl-2 in UUO. Thus, our data suggest that IGF-1 may protect renal tubular epithelial cells via activation of ERK/MAPK signaling pathway during renal injury. |Animals [MESH] |Apoptosis/drug effects [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Epithelial Cells/cytology/drug effects/metabolism [MESH] |Insulin-Like Growth Factor I/*administration & dosage/pharmacology [MESH] |Kidney Diseases/etiology/genetics/metabolism/*prevention & control [MESH] |Kidney Tubules/cytology/*drug effects/metabolism [MESH] |MAP Kinase Signaling System/*drug effects [MESH] |Male [MESH] |Mice [MESH] |MicroRNAs/genetics [MESH] |Proto-Oncogene Proteins c-bcl-2/genetics/metabolism [MESH]IGF-1 protects tubular epithelial cells during injury via activation o(epmc).pdf DeepDyve Pubget Overpricing