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10.1038/srep27909 http://scihub22266oqcxt.onion/10.1038/srep27909 C4908401!4908401!27302413     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27302413|t=2016. Structure of neprilysin in complex with the active metabolite of sacubitril |pdf=|usr=}}{{27302413}} gab.com Text Structure of neprilysin in complex with the active metabolite of sacubitril JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27302413 #FOAvip Sacubitril is an ethyl ester prodrug of LBQ657, the active neprilysin (NEP) inhibitor, and a component of LCZ696 (sacubitril/valsartan). We report herein the three-dimensional structure of LBQ657 in complex with human NEP at 2?Å resolution. The crystal structure unravels the binding mode of the compound occupying the S1, S1? and S2? sub-pockets of the active site, consistent with a competitive inhibition mode. An induced fit conformational change upon binding of the P1?-biphenyl moiety of the inhibitor suggests an explanation for its selectivity against structurally homologous zinc metallopeptidases. Twit Text FOAVip Structure of neprilysin in complex with the active metabolite of sacubitril ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27302413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27302413 #FOAvip English Wikipedia <ref>{{Cite pmid|27302413}}</ref> Structure of neprilysin in complex with the active metabolite of sacubitril #MMPMID27302413 Schiering N; D?Arcy A; Villard F; Ramage P; Logel C; Cumin F; Ksander GM; Wiesmann C; Karki RG; Mogi M Sci Rep 2016[]; 6 (ä): ä PMID27302413show ga Sacubitril is an ethyl ester prodrug of LBQ657, the active neprilysin (NEP) inhibitor, and a component of LCZ696 (sacubitril/valsartan). We report herein the three-dimensional structure of LBQ657 in complex with human NEP at 2?Å resolution. The crystal structure unravels the binding mode of the compound occupying the S1, S1? and S2? sub-pockets of the active site, consistent with a competitive inhibition mode. An induced fit conformational change upon binding of the P1?-biphenyl moiety of the inhibitor suggests an explanation for its selectivity against structurally homologous zinc metallopeptidases. äStructure of neprilysin in complex with the active metabolite of sacub(epmc).pdf DeepDyve Pubget Overpricing