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10.1111/cei.12790 http://scihub22266oqcxt.onion/10.1111/cei.12790 C4908292!4908292!26969967     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2016 ; 185 (1): 86-97 Nephropedia Template TP {{tp|p=26969967|t=2016. 17??Oestradiol enhances the expansion and activation of myeloid?derived suppressor cells via signal transducer and activator of transcription (STAT)?3 signalling in human pregnancy |pdf=|usr=}}{{26969967}} gab.com Text 17 Oestradiol enhances the expansion and activation of myeloid derived suppressor cells via signal transducer and activator of transcription (STAT) 3 signalling in human pregnancy JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26969967 #FOAvip During a successful pregnancy, the maternal immune system plays a critical role in maintaining immunotolerance towards semi?allogeneic fetal antigens. Recent studies have indicated that myeloid?derived suppressor cells (MDSCs) are active players in establishing fetal?maternal tolerance; however, the underlying mechanism remains poorly understood. In this study, we observed a significant expansion of monocytic MDSCs (M?MDSCs) in the peripheral blood of pregnant women, which suppressed T cell responses in a reactive oxygen species?dependent manner and required cell?cell contact. The number of M?MDSCs correlated positively with serum oestrogen and progesterone levels. Administration of 17??oestradiol, but not progesterone, enhanced both the expansion and suppressive activity of M?MDSCs through signal transducer and activator of transcription (STAT)?3. Pretreatment with STAT?3 inhibitor JSI?124 almost completely abrogated the effects of 17??oestradiol on MDSCs. Collectively, these results demonstrate that 17??oestradiol?induced STAT?3 signalling plays an important role in both the expansion and activation of MDSCs during human pregnancy, which may benefit the development of novel therapeutic strategies for prevention of immune?related miscarriage. Twit Text FOAVip 17 Oestradiol enhances the expansion and activation of myeloid derived suppressor cells via signal transducer and activator of transcription (STAT) 3 signalling in human pregnancy ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26969967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26969967 #FOAvip English Wikipedia <ref>{{Cite pmid|26969967}}</ref> 17??Oestradiol enhances the expansion and activation of myeloid?derived suppressor cells via signal transducer and activator of transcription (STAT)?3 signalling in human pregnancy #MMPMID26969967 Pan T; Zhong L; Wu S; Cao Y; Yang Q; Cai Z; Cai X; Zhao W; Ma N; Zhang W; Zhang H; Zhou J Clin Exp Immunol 2016[Jul]; 185 (1): 86-97 PMID26969967show ga During a successful pregnancy, the maternal immune system plays a critical role in maintaining immunotolerance towards semi?allogeneic fetal antigens. Recent studies have indicated that myeloid?derived suppressor cells (MDSCs) are active players in establishing fetal?maternal tolerance; however, the underlying mechanism remains poorly understood. In this study, we observed a significant expansion of monocytic MDSCs (M?MDSCs) in the peripheral blood of pregnant women, which suppressed T cell responses in a reactive oxygen species?dependent manner and required cell?cell contact. The number of M?MDSCs correlated positively with serum oestrogen and progesterone levels. Administration of 17??oestradiol, but not progesterone, enhanced both the expansion and suppressive activity of M?MDSCs through signal transducer and activator of transcription (STAT)?3. Pretreatment with STAT?3 inhibitor JSI?124 almost completely abrogated the effects of 17??oestradiol on MDSCs. Collectively, these results demonstrate that 17??oestradiol?induced STAT?3 signalling plays an important role in both the expansion and activation of MDSCs during human pregnancy, which may benefit the development of novel therapeutic strategies for prevention of immune?related miscarriage. ä17??Oestradiol enhances the expansion and activation of myeloid?derive(epmc).pdf DeepDyve Pubget Overpricing