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10.1155/2016/5258727 http://scihub22266oqcxt.onion/10.1155/2016/5258727 C4908263!4908263!27340661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=27340661|t=2016. Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences |pdf=|usr=}}{{27340661}} gab.com Text Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=27340661 #FOAvip Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased mucociliary clearance, bacterial colonisation, and chronic neutrophil-dominated inflammation. Much knowledge surrounding the pathophysiology of the disease has been gained through the generation of animal models, despite inherent limitations in each. The failure of certain mouse models to recapitulate the phenotypic manifestations of human disease has initiated the generation of larger animals in which to study CF, including the pig and the ferret. This review will summarise the basic phenotypes of three animal models and describe the contributions of such animal studies to our current understanding of CF. Twit Text FOAVip Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=27340661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27340661 #FOAvip English Wikipedia <ref>{{Cite pmid|27340661}}</ref> Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences #MMPMID27340661 Lavelle GM; White MM; Browne N; McElvaney NG; Reeves EP Biomed Res Int 2016[]; 2016 (ä): ä PMID27340661show ga Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased mucociliary clearance, bacterial colonisation, and chronic neutrophil-dominated inflammation. Much knowledge surrounding the pathophysiology of the disease has been gained through the generation of animal models, despite inherent limitations in each. The failure of certain mouse models to recapitulate the phenotypic manifestations of human disease has initiated the generation of larger animals in which to study CF, including the pig and the ferret. This review will summarise the basic phenotypes of three animal models and describe the contributions of such animal studies to our current understanding of CF. äAnimal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and D(epmc).pdf DeepDyve Pubget Overpricing