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suck abstract from ncbi


10.1016/j.drudis.2016.05.015

http://scihub22266oqcxt.onion/10.1016/j.drudis.2016.05.015
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C4907866!4907866!27240777
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suck abstract from ncbi


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pmid27240777      Drug+Discov+Today 2016 ; 21 (7): 1189-95
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  • Drug combination therapy increases successful drug repositioning #MMPMID27240777
  • Sun W; Sanderson P; Zheng W
  • Drug Discov Today 2016[Jul]; 21 (7): 1189-95 PMID27240777show ga
  • Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tolerated plasma drug concentrations are lower than the required therapeutic drug concentrations. Drug combinations of two or more compounds with different mechanisms of action are an alternative approach to increase the success rate of drug repositioning.
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