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10.1016/j.cbpa.2016.01.009 http://scihub22266oqcxt.onion/10.1016/j.cbpa.2016.01.009 C4907839!4907839!26859714     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Chem+Biol 2016 ; 32 (ä): 10-21 Nephropedia Template TP {{tp|p=26859714|t=2016. A Current Pharmacologic Agent versus The Promise of Next Generation Therapeutics to Ameliorate Protein Misfolding and/or Aggregation Diseases |pdf=|usr=}}{{26859714}} gab.com Text A Current Pharmacologic Agent versus The Promise of Next Generation Therapeutics to Ameliorate Protein Misfolding and/or Aggregation Diseases JO: Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26859714 #FOAvip The list of protein aggregation-associated degenerative diseases is long and growing, while the portfolio of disease-modifying strategies is very small. In this review and perspective, we assess what has worked to slow the progression of an aggregation-associated degenerative disease, covering the underlying mechanism of pharmacologic action and what we have learned about the etiology of the transthyretin amyloid diseases and likely amyloidoses in general. Finally, we introduce emerging therapies that should apply more generally to protein misfolding and/or aggregation diseases that rely on adapting the protein homeostasis or proteostasis network for disease amelioration. Twit Text FOAVip A Current Pharmacologic Agent versus The Promise of Next Generation Therapeutics to Ameliorate Protein Misfolding and/or Aggregation Diseases ????Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26859714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26859714 #FOAvip English Wikipedia <ref>{{Cite pmid|26859714}}</ref> A Current Pharmacologic Agent versus The Promise of Next Generation Therapeutics to Ameliorate Protein Misfolding and/or Aggregation Diseases #MMPMID26859714 Baranczak A; Kelly JW Curr Opin Chem Biol 2016[Jun]; 32 (ä): 10-21 PMID26859714show ga The list of protein aggregation-associated degenerative diseases is long and growing, while the portfolio of disease-modifying strategies is very small. In this review and perspective, we assess what has worked to slow the progression of an aggregation-associated degenerative disease, covering the underlying mechanism of pharmacologic action and what we have learned about the etiology of the transthyretin amyloid diseases and likely amyloidoses in general. Finally, we introduce emerging therapies that should apply more generally to protein misfolding and/or aggregation diseases that rely on adapting the protein homeostasis or proteostasis network for disease amelioration. äA Current Pharmacologic Agent versus The Promise of Next Generation Th(epmc).pdf DeepDyve Pubget Overpricing