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2016 ; 11
(ä): 2505-13
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Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal
injections of 18 nm gold nanoparticles in hamsters
#MMPMID27354788
Saleh HM
; Soliman OA
; Elshazly MO
; Raafat A
; Gohar AK
; Salaheldin TA
Int J Nanomedicine
2016[]; 11
(ä): 2505-13
PMID27354788
show ga
In vivo responses to gold nanoparticles (GNPs) vary not only according to the
size, shape, surface charge, and capping agent of GNPs but also according to the
animal model, the route of administration, and the exposure frequency and
duration. We illustrate here the changes in some hematologic parameters, in the
hepatic and renal functions, and in the histopathology of solid organs after
multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden
hamsters. We scored the histopathological changes in the liver and kidneys to
grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs
in hamsters were nonlethal in the short term but resulted in macrocytosis and
hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The
hepatic and renal functions showed nonsignificant changes; however,
histopathological examination showed hepatic and renal alterations ranging from
mild to marked degeneration, with occasional necrosis of hepatocytes and tubular
epithelium.