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10.1016/j.cell.2016.04.038 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.04.038 C4907330!4907330!27203113     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 165 (5): 1280-92 Nephropedia Template TP {{tp|p=27203113|t=2016. Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape |pdf=|usr=}}{{27203113}} gab.com Text Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27203113 #FOAvip The cistrome is the complete set of transcription factor (TF) binding sites (cis-elements) in an organism, while an epicistrome incorporates tissue-specific DNA chemical modifications and TF-specific chemical sensitivities into these binding profiles. Robust methods to construct comprehensive cistrome and epicistrome maps are critical for elucidating complex transcriptional networks that underlie growth, behavior, and disease. Here, we describe DNA affinity purification sequencing (DAP-seq), a high-throughput TF binding site discovery method that interrogates genomic DNA with in-vitro-expressed TFs. Using DAP-seq, we defined the Arabidopsis cistrome by resolving motifs and peaks for 529 TFs. Because genomic DNA used in DAP-seq retains 5-methylcytosines, we determined that >75% (248/327) of Arabidopsis TFs surveyed were methylation sensitive, a property that strongly impacts the epicistrome landscape. DAP-seq datasets also yielded insight into the biology and binding site architecture of numerous TFs, demonstrating the value of DAP-seq for cost-effective cistromic and epicistromic annotation in any organism. Twit Text FOAVip Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27203113 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27203113 #FOAvip English Wikipedia <ref>{{Cite pmid|27203113}}</ref> Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape #MMPMID27203113 O?Malley RC; Huang SsC; Song L; Lewsey MG; Bartlett A; Nery JR; Galli M; Gallavotti A; Ecker JR Cell 2016[May]; 165 (5): 1280-92 PMID27203113show ga The cistrome is the complete set of transcription factor (TF) binding sites (cis-elements) in an organism, while an epicistrome incorporates tissue-specific DNA chemical modifications and TF-specific chemical sensitivities into these binding profiles. Robust methods to construct comprehensive cistrome and epicistrome maps are critical for elucidating complex transcriptional networks that underlie growth, behavior, and disease. Here, we describe DNA affinity purification sequencing (DAP-seq), a high-throughput TF binding site discovery method that interrogates genomic DNA with in-vitro-expressed TFs. Using DAP-seq, we defined the Arabidopsis cistrome by resolving motifs and peaks for 529 TFs. Because genomic DNA used in DAP-seq retains 5-methylcytosines, we determined that >75% (248/327) of Arabidopsis TFs surveyed were methylation sensitive, a property that strongly impacts the epicistrome landscape. DAP-seq datasets also yielded insight into the biology and binding site architecture of numerous TFs, demonstrating the value of DAP-seq for cost-effective cistromic and epicistromic annotation in any organism. äCistrome and Epicistrome Features Shape the Regulatory DNA Landscape (epmc).pdf DeepDyve Pubget Overpricing