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10.1016/j.it.2015.09.008 http://scihub22266oqcxt.onion/10.1016/j.it.2015.09.008 C4907328!4907328!26494046     free     free     free       Trends+Immunol 2015 ; 36 (11): 709-24 Nephropedia Template TP {{tp|p=26494046|t=2015. Antibodies as Mediators of Brain Pathology |pdf=|usr=}}{{26494046}} gab.com Text Antibodies as Mediators of Brain Pathology JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26494046 #FOAvip The brain is normally sequestered from antibody exposure by the blood brain barrier. However, antibodies can access the brain during fetal development before the barrier achieves full integrity, and in disease states when barrier integrity is compromised. Recent studies suggest that antibodies contribute to brain pathology associated with autoimmune diseases such as systemic lupus erythematosus and neuromyelitis optica, and can lead to transient or permanent behavioral or cognitive abnormalities. We review these findings here and examine the circumstances associated with antibody entry into the brain, the routes of access and the mechanisms that then effect pathology. Understanding these processes and the nature and specificity of neuronal autoantibodies may reveal therapeutic strategies toward alleviating or preventing the neurological pathologies and behavioral abnormalities associated with autoimmune disease. Twit Text FOAVip Antibodies as Mediators of Brain Pathology ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26494046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26494046 #FOAvip English Wikipedia <ref>{{Cite pmid|26494046}}</ref> Antibodies as Mediators of Brain Pathology #MMPMID26494046 Brimberg L; Mader S; Fujieda Y; Arinuma Y; Kowal C; Volpe BT; Diamond B Trends Immunol 2015[Nov]; 36 (11): 709-24 PMID26494046show ga The brain is normally sequestered from antibody exposure by the blood brain barrier. However, antibodies can access the brain during fetal development before the barrier achieves full integrity, and in disease states when barrier integrity is compromised. Recent studies suggest that antibodies contribute to brain pathology associated with autoimmune diseases such as systemic lupus erythematosus and neuromyelitis optica, and can lead to transient or permanent behavioral or cognitive abnormalities. We review these findings here and examine the circumstances associated with antibody entry into the brain, the routes of access and the mechanisms that then effect pathology. Understanding these processes and the nature and specificity of neuronal autoantibodies may reveal therapeutic strategies toward alleviating or preventing the neurological pathologies and behavioral abnormalities associated with autoimmune disease. äAntibodies as Mediators of Brain Pathology (epmc).pdf DeepDyve Pubget Overpricing