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10.1128/IAI.00138-16 http://scihub22266oqcxt.onion/10.1128/IAI.00138-16 C4907134!4907134!27001537     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Immun 2016 ; 84 (6): 1672-81 Nephropedia Template TP {{tp|p=27001537|t=2016. Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus |pdf=|usr=}}{{27001537}} gab.com Text Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus JO: Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=27001537 #FOAvip Excretion of cytoplasmic proteins in pro- and eukaryotes, also referred to as ?nonclassical protein export,? is a well-known phenomenon. However, comparatively little is known about the role of the excreted proteins in relation to pathogenicity. Here, the impact of two excreted glycolytic enzymes, aldolase (FbaA) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), on pathogenicity was investigated in Staphylococcus aureus. Both enzymes bound to certain host matrix proteins and enhanced adherence of the bacterial cells to host cells but caused a decrease in host cell invasion. FbaA and GAPDH also bound to the cell surfaces of staphylococcal cells by interaction with the major autolysin, Atl, that is involved in host cell internalization. Surprisingly, FbaA showed high cytotoxicity to both MonoMac 6 (MM6) and HaCaT cells, while GAPDH was cytotoxic only for MM6 cells. Finally, the contribution of external FbaA and GAPDH to S. aureus pathogenicity was confirmed in an insect infection model. Twit Text FOAVip Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus ????Infect Immun http://www.kidney.de/pget.php?&tw=1&pmid=27001537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27001537 #FOAvip English Wikipedia <ref>{{Cite pmid|27001537}}</ref> Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus #MMPMID27001537 Ebner P; Rinker J; Nguyen MT; Popella P; Nega M; Luqman A; Schittek B; Di Marco M; Stevanovic S; Götz F Infect Immun 2016[Jun]; 84 (6): 1672-81 PMID27001537show ga Excretion of cytoplasmic proteins in pro- and eukaryotes, also referred to as ?nonclassical protein export,? is a well-known phenomenon. However, comparatively little is known about the role of the excreted proteins in relation to pathogenicity. Here, the impact of two excreted glycolytic enzymes, aldolase (FbaA) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), on pathogenicity was investigated in Staphylococcus aureus. Both enzymes bound to certain host matrix proteins and enhanced adherence of the bacterial cells to host cells but caused a decrease in host cell invasion. FbaA and GAPDH also bound to the cell surfaces of staphylococcal cells by interaction with the major autolysin, Atl, that is involved in host cell internalization. Surprisingly, FbaA showed high cytotoxicity to both MonoMac 6 (MM6) and HaCaT cells, while GAPDH was cytotoxic only for MM6 cells. Finally, the contribution of external FbaA and GAPDH to S. aureus pathogenicity was confirmed in an insect infection model. äExcreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphyloc(epmc).pdf DeepDyve Pubget Overpricing