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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biomed+Semantics
2016 ; 7
(ä): 39
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English Wikipedia
FALDO: a semantic standard for describing the location of nucleotide and protein
feature annotation
#MMPMID27296299
Bolleman JT
; Mungall CJ
; Strozzi F
; Baran J
; Dumontier M
; Bonnal RJ
; Buels R
; Hoehndorf R
; Fujisawa T
; Katayama T
; Cock PJ
J Biomed Semantics
2016[Jun]; 7
(ä): 39
PMID27296299
show ga
BACKGROUND: Nucleotide and protein sequence feature annotations are essential to
understand biology on the genomic, transcriptomic, and proteomic level. Using
Semantic Web technologies to query biological annotations, there was no standard
that described this potentially complex location information as
subject-predicate-object triples. DESCRIPTION: We have developed an ontology, the
Feature Annotation Location Description Ontology (FALDO), to describe the
positions of annotated features on linear and circular sequences. FALDO can be
used to describe nucleotide features in sequence records, protein annotations,
and glycan binding sites, among other features in coordinate systems of the
aforementioned "omics" areas. Using the same data format to represent sequence
positions that are independent of file formats allows us to integrate sequence
data from multiple sources and data types. The genome browser JBrowse is used to
demonstrate accessing multiple SPARQL endpoints to display genomic feature
annotations, as well as protein annotations from UniProt mapped to genomic
locations. CONCLUSIONS: Our ontology allows users to uniformly describe - and
potentially merge - sequence annotations from multiple sources. Data sources
using FALDO can prospectively be retrieved using federalised SPARQL queries
against public SPARQL endpoints and/or local private triple stores.