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10.1186/s40360-016-0066-9

http://scihub22266oqcxt.onion/10.1186/s40360-016-0066-9
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suck abstract from ncbi


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pmid27296673      BMC+Pharmacol+Toxicol 2016 ; 17 (ä): ä
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  • Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal allograft recipients: an observational study #MMPMID27296673
  • Aly MG; Trojan K; Weimer R; Morath C; Opelz G; Tohamy MA; Daniel V
  • BMC Pharmacol Toxicol 2016[]; 17 (ä): ä PMID27296673show ga
  • Background: Regulatory T cells (Tregs) are a cornerstone of graft acceptance. High numbers of Tregs are associated with better long-term graft survival. Recently, Vitamin D was suggested as an immunomodulator, in addition to its classical role in calcium metabolism. Vitamin D modulates Tregs and might, thereby, promote graft acceptance and long-term graft survival. Methods: One hundred twenty-three renal allograft recipients attending either Heidelberg nephrology or Giessen internal medicine clinic were enrolled in this cross- sectional study. Sixteen healthy controls were studied in addition. Sixty-nine patients were receiving no vitamin D, 38 calcitriol, and 16 cholecalciferol supplementations. We evaluated whether there was a difference in the absolute numbers of Helios+, Helios?, CTLA-4+, IFNg+, and total Tregs among the patient groups. Results: Cholecalciferol supplementation was associated with higher absolute numbers of Helios+, CTLA-4+, and total Tregs than calcitriol (p?
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