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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Pharmacol+Toxicol 2016 ; 17 (ä): ä Nephropedia Template TP
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Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal allograft recipients: an observational study #MMPMID27296673
Aly MG; Trojan K; Weimer R; Morath C; Opelz G; Tohamy MA; Daniel V
BMC Pharmacol Toxicol 2016[]; 17 (ä): ä PMID27296673show ga
Background: Regulatory T cells (Tregs) are a cornerstone of graft acceptance. High numbers of Tregs are associated with better long-term graft survival. Recently, Vitamin D was suggested as an immunomodulator, in addition to its classical role in calcium metabolism. Vitamin D modulates Tregs and might, thereby, promote graft acceptance and long-term graft survival. Methods: One hundred twenty-three renal allograft recipients attending either Heidelberg nephrology or Giessen internal medicine clinic were enrolled in this cross- sectional study. Sixteen healthy controls were studied in addition. Sixty-nine patients were receiving no vitamin D, 38 calcitriol, and 16 cholecalciferol supplementations. We evaluated whether there was a difference in the absolute numbers of Helios+, Helios?, CTLA-4+, IFNg+, and total Tregs among the patient groups. Results: Cholecalciferol supplementation was associated with higher absolute numbers of Helios+, CTLA-4+, and total Tregs than calcitriol (p?0.001, p?=?0.004, p?=?0.001 respectively). Helios+ Tregs were also higher in cholecalciferol than no vitamin D supplementation patients (p?=?0.001), whereas CTLA-4+ and total Tregs were similar in both groups (p?=?NS). Helios+, Helios?, CTLA-4+, IFNg+, and total Tregs were similar in the cholecalciferol and healthy control groups (p?=?NS). Conclusion: Our findings indicate that cholecalciferol, even when administered at low dosages, has a stabilizing effect on Tregs (particularly the Helios?+?subset), in contrast to calcitriol which showed neither a stabilizing nor a proliferation-inducing effect on the same cell population.