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2016 ; 12
(1
): 437-444
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English Wikipedia
Network analysis of microRNAs, transcription factors, target genes and host genes
in human anaplastic astrocytoma
#MMPMID27347075
Xue L
; Xu Z
; Wang K
; Wang N
; Zhang X
; Wang S
Exp Ther Med
2016[Jul]; 12
(1
): 437-444
PMID27347075
show ga
Numerous studies have investigated the roles played by various genes and
microRNAs (miRNAs) in neoplasms, including anaplastic astrocytoma (AA). However,
the specific regulatory mechanisms involving these genes and miRNAs remain
unclear. In the present study, associated biological factors (miRNAs,
transcription factors, target genes and host genes) from existing studies of
human AA were combined methodically through the interactions between genes and
miRNAs, as opposed to studying one or several. Three regulatory networks,
including abnormally expressed, related and global networks were constructed with
the aim of identifying significant gene and miRNA pathways. Each network is
composed of three associations between miRNAs targeted at genes, transcription
factors (TFs) regulating miRNAs and miRNAs located on their host genes. Among
these, the abnormally expressed network, which involves the pathways of
previously identified abnormally expressed genes and miRNAs, partially indicated
the regulatory mechanism underlying AA. The network contains numerous abnormal
regulation associations when AA emerges. By modifying the abnormally expressed
network factors to a normal expression pattern, the faulty regulation may be
corrected and tumorigenesis of AA may be prevented. Certain specific pathways are
highlighted in AA, for example PTEN which is targeted by miR-21 and miR-106b,
regulates miR-25 which in turn targets TP53. PTEN and miR-21 have been observed
to form feedback loops. Furthermore, by comparing and analyzing the pathway
predecessors and successors of abnormally expressed genes and miRNAs in three
networks, similarities and differences of regulatory pathways may be identified
and proposed. In summary, the present study aids in elucidating the occurrence,
mechanism, prevention and treatment of AA. These results may aid further
investigation into therapeutic approaches for this disease.
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