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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Vet+Res 2016 ; 12 (ä): ä Nephropedia Template TP
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Association of anticardiolipin, antiphosphatidylserine, anti-?2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia #MMPMID27297331
Chen YC; Chi LM; Chow KC; Chiou SH; Fan YH; Ho SP; Hsu YC; Hwang YC; Wu MX; Lee WM; Lin SL; Tsang CL; Mao FC
BMC Vet Res 2016[]; 12 (ä): ä PMID27297331show ga
Background: In humans, the presence of antiphospholipid antibodies (aPL) is frequently found in immune thrombocytopenia. The present study investigated whether aPL and any aPL subtypes are associated with canine thrombocytopenia, in particular, immune-mediated thrombocytopenia (immune thrombocytopenia) that usually manifests with severe thrombocytopenia. Results: Sera were collected from 64 outpatient dogs with thrombocytopenia (Group I, platelet count 0 ? 80?×?103/uL), and 38 of which having severe thrombocytopenia (platelet count?30?×?103/uL) were further divided into subgroups based on the presence of positive antiplatelet antibodies (aPLT) (subgroup IA, immune thrombocytopenia, n =20) or the absence of aPLT (subgroup IB, severe thrombocytopenia negative for aPLT, n =18). In addition, sera of 30 outpatient dogs without thrombocytopenia (Group II), and 80 healthy dogs (Group III) were analyzed for comparison. Indirect ELISAs were performed to compare serum levels of aPL subtypes, including anticardiolipin antibodies (aCL), antiphosphatidylserine antibodies (aPS), antiphosphatidylcholine (aPC), and anti-?2 glycoprotein I antibodies (a?2GPI), and antiphosphatidylinositol antibodies (aPI), among different groups or subgroups of dogs. Among outpatient dogs, aCL, being highly prevalent in outpatient dogs with thrombocytopenia (63/64, 98 %), is an important risk factor for thrombocytopenia (with a high relative risk of 8.3), immune thrombocytopenia (relative risk 5.3), or severe thrombocytopenia negative for aPLT (relative risk ?, odds ratio 19). In addition, aPS is a risk factor for immune thrombocytopenia or severe thrombocytopenia negative for aPLT (moderate relative risks around 2), whereas aPC and a?2GPI are risk factors for immune thrombocytopenia (relative risks around 2). Conclusions: Of all the aPL subtypes tested here, aCL is highly associated with canine thrombocytopenia, including immune thrombocytopenia, severe thrombocytopenia negative for aPLT, and less severe thrombocytopenia. Furthermore, aPS is moderately associated with both canine immune thrombocytopenia and severe thrombocytopenia negative for aPLT, whereas a?2GPI, and aPC are moderately relevant to canine immune thrombocytopenia. In contrast, aPI is not significantly associated with canine immune thrombocytopenia. Electronic supplementary material: The online version of this article (doi:10.1186/s12917-016-0727-3) contains supplementary material, which is available to authorized users.