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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2016 ; 7
(ä): 11827
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Associative-memory representations emerge as shared spatial patterns of theta
activity spanning the primate temporal cortex
#MMPMID27282247
Nakahara K
; Adachi K
; Kawasaki K
; Matsuo T
; Sawahata H
; Majima K
; Takeda M
; Sugiyama S
; Nakata R
; Iijima A
; Tanigawa H
; Suzuki T
; Kamitani Y
; Hasegawa I
Nat Commun
2016[Jun]; 7
(ä): 11827
PMID27282247
show ga
Highly localized neuronal spikes in primate temporal cortex can encode
associative memory; however, whether memory formation involves area-wide
reorganization of ensemble activity, which often accompanies rhythmicity, or just
local microcircuit-level plasticity, remains elusive. Using high-density
electrocorticography, we capture local-field potentials spanning the monkey
temporal lobes, and show that the visual pair-association (PA) memory is encoded
in spatial patterns of theta activity in areas TE, 36, and, partially, in the
parahippocampal cortex, but not in the entorhinal cortex. The theta patterns
elicited by learned paired associates are distinct between pairs, but similar
within pairs. This pattern similarity, emerging through novel PA learning, allows
a machine-learning decoder trained on theta patterns elicited by a particular
visual item to correctly predict the identity of those elicited by its paired
associate. Our results suggest that the formation and sharing of widespread
cortical theta patterns via learning-induced reorganization are involved in the
mechanisms of associative memory representation.