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10.1016/j.chom.2016.05.002 http://scihub22266oqcxt.onion/10.1016/j.chom.2016.05.002 C4906371!4906371!27237364     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2016 ; 19 (6): 837-48 Nephropedia Template TP {{tp|p=27237364|t=2016. Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice |pdf=|usr=}}{{27237364}} gab.com Text Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27237364 #FOAvip Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here termed adipose tissue forms (ATFs), can replicate and were capable of infecting a naive animal. ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included putative fatty acid ?-oxidation enzymes. Consistent with this, ATFs were able to utilize exogenous myristate and form ?-oxidation intermediates, suggesting that ATF parasites can use fatty acids as an external carbon source. These findings identify the adipose tissue as a niche for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness. Twit Text FOAVip Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=27237364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27237364 #FOAvip English Wikipedia <ref>{{Cite pmid|27237364}}</ref> Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice #MMPMID27237364 Trindade S; Rijo-Ferreira F; Carvalho T; Pinto-Neves D; Guegan F; Aresta-Branco F; Bento F; Young S; Pinto A; Van Den Abbeele J; Ribeiro R; Dias S; Smith T; Figueiredo L Cell Host Microbe 2016[Jun]; 19 (6): 837-48 PMID27237364show ga Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach the blood-brain barrier. Working with a well-established mouse model, we discovered that adipose tissue constitutes a third major reservoir for T. brucei. Parasites from adipose tissue, here termed adipose tissue forms (ATFs), can replicate and were capable of infecting a naive animal. ATFs were transcriptionally distinct from bloodstream forms, and the genes upregulated included putative fatty acid ?-oxidation enzymes. Consistent with this, ATFs were able to utilize exogenous myristate and form ?-oxidation intermediates, suggesting that ATF parasites can use fatty acids as an external carbon source. These findings identify the adipose tissue as a niche for T. brucei during its mammalian life cycle and could potentially explain the weight loss associated with sleeping sickness. äTrypanosoma brucei Parasites Occupy and Functionally Adapt to the Adip(epmc).pdf DeepDyve Pubget Overpricing