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10.3109/15622975.2016.1142607 http://scihub22266oqcxt.onion/10.3109/15622975.2016.1142607 C4905687!4905687!26919405     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Biol+Psychiatry 2016 ; 17 (3): 230-8 Nephropedia Template TP {{tp|p=26919405|t=2016. Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: a pilot randomized controlled trial |pdf=|usr=}}{{26919405}} gab.com Text Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: a pilot randomized controlled trial JO: World J Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=26919405 #FOAvip Objectives: We examined the feasibility of a high-dose, 96-hour infusion of ketamine in treatment-resistant depression. Methods: Ten participants were randomized to receive a 96-hour ketamine infusion, titrated as tolerated to a target rate of 0.6mg/kg/hour, while 10 received a 40-minute ketamine infusion (0.5mg/kg). Both groups received clonidine, titrated to a maximum of 0.6mg orally daily, during the infusion to mitigate side effects of ketamine. Participants were followed for eight weeks to examine potential antidepressant effects. Results: All 20 participants completed the infusion. Most participants tolerated the infusion well, with minimal psychotomimetic symptoms or blood pressure elevation despite achieving high ketamine concentrations (mean 424ng/ml for 96-hour arm, 156ng/ml for 40-minute arm). There was no rebound hypertension upon discontinuing clonidine. Rapid and sustained improvement in depressive symptoms was observed in both study groups. Higher ketamine concentration was associated with sustained antidepressant response, and was not with greater psychotomimetic side effects, in the 96-hour arm. Conclusions: This study provides evidence for the feasibility of prolonged ketamine infusions in treatment-resistant depression. Co-administration of clonidine appeared to mitigate ketamine's psychotomimetic effects. Further study is required to investigate the extent to which prolonged ketamine infusions could provide both rapid and sustained improvements in treatment-resistant depression.Clinicaltrials.gov identifier NCT01179009 Twit Text FOAVip Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: a pilot randomized controlled trial ????World J Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=26919405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26919405 #FOAvip English Wikipedia <ref>{{Cite pmid|26919405}}</ref> Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: a pilot randomized controlled trial #MMPMID26919405 Lenze EJ; Farber NB; Kharasch E; Schweiger J; Yingling M; Olney J; Newcomer JW World J Biol Psychiatry 2016[Apr]; 17 (3): 230-8 PMID26919405show ga Objectives: We examined the feasibility of a high-dose, 96-hour infusion of ketamine in treatment-resistant depression. Methods: Ten participants were randomized to receive a 96-hour ketamine infusion, titrated as tolerated to a target rate of 0.6mg/kg/hour, while 10 received a 40-minute ketamine infusion (0.5mg/kg). Both groups received clonidine, titrated to a maximum of 0.6mg orally daily, during the infusion to mitigate side effects of ketamine. Participants were followed for eight weeks to examine potential antidepressant effects. Results: All 20 participants completed the infusion. Most participants tolerated the infusion well, with minimal psychotomimetic symptoms or blood pressure elevation despite achieving high ketamine concentrations (mean 424ng/ml for 96-hour arm, 156ng/ml for 40-minute arm). There was no rebound hypertension upon discontinuing clonidine. Rapid and sustained improvement in depressive symptoms was observed in both study groups. Higher ketamine concentration was associated with sustained antidepressant response, and was not with greater psychotomimetic side effects, in the 96-hour arm. Conclusions: This study provides evidence for the feasibility of prolonged ketamine infusions in treatment-resistant depression. Co-administration of clonidine appeared to mitigate ketamine's psychotomimetic effects. Further study is required to investigate the extent to which prolonged ketamine infusions could provide both rapid and sustained improvements in treatment-resistant depression.Clinicaltrials.gov identifier NCT01179009 äNinety-six hour ketamine infusion with co-administered clonidine for t(epmc).pdf DeepDyve Pubget Overpricing