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10.18632/oncotarget.7317 http://scihub22266oqcxt.onion/10.18632/oncotarget.7317 C4905492!4905492 !26883193     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26883193 &cmd=llinks): Failed to open stream: HTTP request failed! 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Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy |pdf=|usr=}}{{26883193 }} gab.com Text Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26883193 #FOAvip Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies in the treatment of HER2-positive breast cancer is a major clinical problem. To identify pathways linked to resistance, we generated HER2-positive breast cancer cell lines which are resistant to either lapatinib or AZD8931, two pan-HER family kinase inhibitors. Resistance was HER2 independent and was associated with epithelial-to-mesenchymal transition (EMT), resulting in increased proliferation and migration of the resistant cells. Using a global proteomics approach, we identified a novel set of EMT-associated proteins linked to HER2-independent resistance. We demonstrate that a subset of these EMT-associated genes is predictive of prognosis within the ERBB2 subtype of human breast cancers. Furthermore, targeting the EMT-associated kinases Src and Axl potently inhibited proliferation of the resistant cells, and inhibitors to these kinases may provide additional options for the treatment of HER2-independent resistance in tumors. Twit Text FOAVip Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26883193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26883193 #FOAvip English Wikipedia <ref>{{Cite pmid|26883193 }}</ref> Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy #MMPMID26883193 Creedon H ; Gómez-Cuadrado L ; Tarnauskait? ? ; Balla J ; Canel M ; MacLeod KG ; Serrels B ; Fraser C ; Unciti-Broceta A ; Tracey N ; Le Bihan T ; Klinowska T ; Sims AH ; Byron A ; Brunton VG Oncotarget 2016[Mar]; 7 (10 ): 11539-52 PMID26883193 show ga Resistance to human epidermal growth factor receptor 2 (HER2)-targeted therapies in the treatment of HER2-positive breast cancer is a major clinical problem. To identify pathways linked to resistance, we generated HER2-positive breast cancer cell lines which are resistant to either lapatinib or AZD8931, two pan-HER family kinase inhibitors. Resistance was HER2 independent and was associated with epithelial-to-mesenchymal transition (EMT), resulting in increased proliferation and migration of the resistant cells. Using a global proteomics approach, we identified a novel set of EMT-associated proteins linked to HER2-independent resistance. We demonstrate that a subset of these EMT-associated genes is predictive of prognosis within the ERBB2 subtype of human breast cancers. Furthermore, targeting the EMT-associated kinases Src and Axl potently inhibited proliferation of the resistant cells, and inhibitors to these kinases may provide additional options for the treatment of HER2-independent resistance in tumors. |Antineoplastic Agents/*pharmacology [MESH] |Breast Neoplasms/*drug therapy/enzymology/genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Drug Resistance, Neoplasm [MESH] |Epithelial-Mesenchymal Transition [MESH] |Female [MESH] |Humans [MESH] |Lapatinib [MESH] |Molecular Targeted Therapy [MESH] |Prognosis [MESH] |Protein Kinase Inhibitors/*pharmacology [MESH] |Proteomics [MESH] |Quinazolines/pharmacology [MESH] |Receptor, ErbB-2/antagonists & inhibitors/*metabolism [MESH]Identification of novel pathways linking epithelial-to-mesenchymal tra(epmc).pdf DeepDyve Pubget Overpricing