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10.18632/oncotarget.7150 http://scihub22266oqcxt.onion/10.18632/oncotarget.7150 C4905460!4905460 !26848978     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26848978 &cmd=llinks): Failed to open stream: HTTP request failed! 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Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-?-mediated MDSC infiltration |pdf=|usr=}}{{26848978 }} gab.com Text Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP- -mediated MDSC infiltration JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26848978 #FOAvip The oncogenic role of microRNA-155 (miR-155) in leukemia is well established but its role in other cancers, especially breast cancer, is gradually emerging. In this study we examined the effect of mir-155 loss in a well-characterized spontaneous breast cancer mouse model where Brca1 and Trp53 are deleted by K14-Cre. miR-155 is known to be up-regulated in BRCA1-deficient tumors. Surprisingly, complete loss of miR-155 (miR-155ko/ko) did not alter the tumor free survival of the mutant mice. However, we found increased infiltration of myeloid derived suppressor cells (MDSCs) in miR-155 deficient tumors. In addition, cytokine/chemokine array analysis revealed altered level of cytokines that are implicated in the recruitment of MDSCs. Mechanistically, we identified C/EBP-?, a known miR-155 target, to regulate the expression of these cytokines in the miR-155-deficient cells. Furthermore, using an allograft model, we showed that inhibition of miR-155 in cancer cells suppressed in vivo growth, which was restored by the loss of miR-155 in the microenvironment. Taken together, we have uncovered a novel tumor suppressive function of miR-155 in the tumor microenvironment, which is also dependent on miR-155 expression in the tumor cells. Because of the oncogenic as well as tumor suppressive roles of miR-155, our findings warrant caution against a systemic inhibition of miR-155 for anticancer therapy. Twit Text FOAVip Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP- -mediated MDSC infiltration ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26848978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26848978 #FOAvip English Wikipedia <ref>{{Cite pmid|26848978 }}</ref> Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-?-mediated MDSC infiltration #MMPMID26848978 Kim S ; Song JH ; Kim S ; Qu P ; Martin BK ; Sehareen WS ; Haines DC ; Lin PC ; Sharan SK ; Chang S Oncotarget 2016[Mar]; 7 (10 ): 11094-112 PMID26848978 show ga The oncogenic role of microRNA-155 (miR-155) in leukemia is well established but its role in other cancers, especially breast cancer, is gradually emerging. In this study we examined the effect of mir-155 loss in a well-characterized spontaneous breast cancer mouse model where Brca1 and Trp53 are deleted by K14-Cre. miR-155 is known to be up-regulated in BRCA1-deficient tumors. Surprisingly, complete loss of miR-155 (miR-155ko/ko) did not alter the tumor free survival of the mutant mice. However, we found increased infiltration of myeloid derived suppressor cells (MDSCs) in miR-155 deficient tumors. In addition, cytokine/chemokine array analysis revealed altered level of cytokines that are implicated in the recruitment of MDSCs. Mechanistically, we identified C/EBP-?, a known miR-155 target, to regulate the expression of these cytokines in the miR-155-deficient cells. Furthermore, using an allograft model, we showed that inhibition of miR-155 in cancer cells suppressed in vivo growth, which was restored by the loss of miR-155 in the microenvironment. Taken together, we have uncovered a novel tumor suppressive function of miR-155 in the tumor microenvironment, which is also dependent on miR-155 expression in the tumor cells. Because of the oncogenic as well as tumor suppressive roles of miR-155, our findings warrant caution against a systemic inhibition of miR-155 for anticancer therapy. |*MicroRNAs [MESH] |Animals [MESH] |CCAAT-Enhancer-Binding Protein-beta/metabolism [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Mammary Neoplasms, Experimental/*immunology/*pathology [MESH] |Mice [MESH] |Mice, Mutant Strains [MESH] |Myeloid-Derived Suppressor Cells/*immunology [MESH] |Oncogenes [MESH]Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enha(epmc).pdf DeepDyve Pubget Overpricing