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10.1080/23723556.2015.1014219

http://scihub22266oqcxt.onion/10.1080/23723556.2015.1014219
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C4905351!4905351!27308507
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suck abstract from ncbi


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pmid27308507      Mol+Cell+Oncol 2015 ; 2 (4): ä
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  • Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q) #MMPMID27308507
  • Fang J; Starczynowski DT
  • Mol Cell Oncol 2015[Oct]; 2 (4): ä PMID27308507show ga
  • MiR-146a deletion is a driving molecular event in del(5q) myeloid malignancies, which acquire dependency on a nuclear factor kappa B (NF-?B) regulatory network. p62, a neighboring haploid 5q gene, is induced by NF-?B and required to sustain TRAF6-mediated NF-?B activation. Interfering with p62/TRAF6 binding may have a therapeutic benefit in miR-146a?deficient leukemic cells.
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