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10.4161/23723556.2014.975645 http://scihub22266oqcxt.onion/10.4161/23723556.2014.975645 C4905288!4905288!27308453     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27308453&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Mol+Cell+Oncol 2015 ; 2 (3): ä Nephropedia Template TP {{tp|p=27308453|t=2015. Oncosuppressive functions of decorin |pdf=|usr=}}{{27308453}} gab.com Text Oncosuppressive functions of decorin JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308453 #FOAvip The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor. Decorin binds and antagonizes various receptor tyrosine kinases and inhibits downstream oncogenic signaling in several solid tumors. Among other functions, decorin evokes cell cycle arrest, apoptosis, and antimetastatic, and antiangiogenic programs. Recent work has revealed a paradigmatic shift in our understanding of the molecular mechanisms underlying its tumoricidal properties. Decorin adversely compromises the genetic signature of the tumor microenvironment and induces endothelial cell autophagy downstream of VEGFR2. Moreover, decorin selectively evokes destruction of tumor cell mitochondria downstream of Met through mitophagy. Acting as a partial agonist, decorin signals via proautophagic receptors and triggers procatabolic processes that parallel the classical tumoricidal properties of this multifaceted proteoglycan. Twit Text FOAVip Oncosuppressive functions of decorin ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27308453 #FOAvip English Wikipedia <ref>{{Cite pmid|27308453}}</ref> Oncosuppressive functions of decorin #MMPMID27308453 Neill T; Schaefer L; Iozzo RV Mol Cell Oncol 2015[Jul]; 2 (3): ä PMID27308453show ga The extracellular matrix is rapidly emerging as a prominent contributor to various fundamental processes of tumorigenesis. In particular, decorin, a member of the small leucine-rich proteoglycan gene family, is assuming a central role as a potent soluble tumor repressor. Decorin binds and antagonizes various receptor tyrosine kinases and inhibits downstream oncogenic signaling in several solid tumors. Among other functions, decorin evokes cell cycle arrest, apoptosis, and antimetastatic, and antiangiogenic programs. Recent work has revealed a paradigmatic shift in our understanding of the molecular mechanisms underlying its tumoricidal properties. Decorin adversely compromises the genetic signature of the tumor microenvironment and induces endothelial cell autophagy downstream of VEGFR2. Moreover, decorin selectively evokes destruction of tumor cell mitochondria downstream of Met through mitophagy. Acting as a partial agonist, decorin signals via proautophagic receptors and triggers procatabolic processes that parallel the classical tumoricidal properties of this multifaceted proteoglycan. äOncosuppressive functions of decorin (epmc).pdf DeepDyve Pubget Overpricing