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10.4161/23723548.2014.968043

http://scihub22266oqcxt.onion/10.4161/23723548.2014.968043
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suck abstract from ncbi


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pmid27308448
      Mol+Cell+Oncol 2015 ; 2 (3 ): e968043
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  • Paving the way for therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide #MMPMID27308448
  • Porporato PE ; Sonveaux P
  • Mol Cell Oncol 2015[Jul]; 2 (3 ): e968043 PMID27308448 show ga
  • Metastatic dissemination is associated with poor prognosis of cancer patients. While exploring glucose metabolism in metastatic progenitor cells, we recently found that several different dysfunctions that share the ability to induce mitochondrial superoxide production also promote tumor metastasis. Selective targeting of mitochondrial superoxide prevented spontaneous metastasis in mice, opening a new avenue for therapy.
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